Results 31 to 40 of about 5,806,183 (351)

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum

Journal of Lipid Research, 2011
Apolipoprotein CIII (apoCIII), a major constituent of triglyceride-rich lipoprotein, has been proposed as a key contributor to hypertriglyceridemia on the basis of its inhibitory effects on lipoprotein lipase.
Yuxin Wang, Zhili Song, Janice D. Wagner, Catherine Pachuk, Romesh R. Subramanian   +4 more
doaj   +1 more source

A multicontrast MR atlas of the Wistar rat brain

NeuroImage, 2021
We describe a multi-contrast, multi-dimensional atlas of the Wistar rat acquired at microscopic spatial resolution using magnetic resonance histology (MRH). Diffusion weighted images, and associated scalar images were acquired of a single specimen with a
G. Allan Johnson, Rick Laoprasert, Robert J. Anderson, Gary Cofer, James Cook, Forrest Pratson, Leonard E. White   +6 more
doaj   +1 more source

Technical Development of a New Semispherical Radiofrequency Bipolar Device (RONJA): Ex Vivo and In Vivo Studies [PDF]

, 2014
The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation.
Crha, M, Delongova, P, Grepl, J, Habib, NA, Hasal, M, Ihnat, P, Jurcikova, J, Nowakova, J, Ostruszka, P, Palecek, J, Penhaker, M, Salounova, D, Skrobankova, M, Vavra, P, Zonca, P   +14 more
core   +5 more sources

CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma

OncoImmunology, 2021
Multiple myeloma (MM) is a hematological malignancy characterized by the presence of clonal plasma cells in the bone marrow niche. Despite significant therapeutic advances, MM remains incurable for the majority of patients. Targeted radionuclide therapy (
Kim De Veirman, Janik Puttemans, Ahmet Krasniqi, Thomas Ertveldt, Heleen Hanssens, Ema Romao, Dirk Hose, Cleo Goyvaert, Philip Vlummens, Serge Muyldermans, Karine Breckpot, Frank Bruchertseifer, Alfred Morgenstern, Matthias D’Huyvetter, Nick Devoogdt   +14 more
doaj   +1 more source

Techniques for RNA in vivo imaging in plants [PDF]

, 2014
Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core   +1 more source

Learnings and challenges to deploy an interprofessional and independent medical education programme to a new audience

Journal of European CME, 2017
The importance of interprofessional education (IPE) in continuing medical education and professional development has long been recognised by health organisations and academic societies, benefiting not only patient outcomes and interprofessional ...
Mieke L. Van Driel, Treasure M. McGuire, Richard Stark, Patrice Lazure, Tina Garcia, Lisa Sullivan   +5 more
doaj   +1 more source

Predicting unipolar and bipolar depression using inflammatory markers, neuroimaging and neuropsychological data: a machine learning study

European Psychiatry, 2023
Introduction About 60% of bipolar disorder (BD) cases are initially misdiagnosed as major depressive disorder (MDD), preventing BD patients from receiving appropriate treatment.
L. Raffaelli, F. Colombo, F. Calesella, L. Fortaner-Uya, I. Bollettini, C. Lorenzi, E. Maggioni, E. Tassi, S. Poletti, R. Zanardi, F. Attanasio, F. Benedetti, B. Vai   +12 more
doaj   +1 more source

Inverse modelling of image-based patient-specific blood vessels : zero-pressure geometry and in vivo stress incorporation [PDF]

, 2013
In vivo visualization of cardiovascular structures is possible using medical images. However, one has to realize that the resulting 3D geometries correspond to in vivo conditions.
Bols, Joris, Degroote, Joris, Segers, Patrick, Trachet, Bram, Verhegghe, Benedict, Vierendeels, Jan   +5 more
core   +3 more sources

The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery

Biomolecules, 2021
Intraoperative guidance using targeted fluorescent tracers can potentially provide surgeons with real-time feedback on the presence of tumor tissue in resection margins.
Pieterjan Debie, Noemi B. Declerck, Danny van Willigen, Celine M. Huygen, Bieke De Sloovere, Lukasz Mateusiak, Jessica Bridoux, Janik Puttemans, Nick Devoogdt, Fijs W. B. van Leeuwen, Sophie Hernot   +10 more
doaj   +1 more source