Results 51 to 60 of about 6,961,893 (372)

The Canmore Declaration: Statement of Principles for Planetary Health

open access: yesChallenges, 2018
The term planetary health—denoting the interdependence between human health and place at all scales—emerged from the environmental and preventive health movements of the 1970–80s; in 1980, Friends of the Earth expanded the World Health Organization ...
Susan L. Prescott   +15 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

open access: yesNeuroImage, 2023
Sleep has been suggested to contribute to myelinogenesis and associated structural changes in the brain. As a principal hallmark of sleep, slow-wave activity (SWA) is homeostatically regulated but also differs between individuals. Besides its homeostatic
Michele Deantoni   +21 more
doaj  

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases

open access: yesPharmaceutics, 2019
Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities.
Janik Puttemans   +3 more
doaj   +1 more source

In vivo labeling and quantitative imaging of neurons using MRI [PDF]

open access: yesarXiv, 2022
Mammalian brain is a complex organ that contains billions of neurons. These neurons form various neural circuits that control the perception, cognition, emotion and behavior. Developing in vivo neuronal labeling and imaging techniques is crucial for studying the structure and function of neural circuits.
arxiv  

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

Circadian regulation of human cortical excitability

open access: yesNature Communications, 2016
Cognitive performance is impaired after prolonged wakefulness, yet the contribution of circadian rhythms for proper brain function remains unclear. Here the authors show that cortical excitability measured using TMS exhibits robust circadian dynamics ...
Julien Q. M. Ly   +15 more
doaj   +1 more source

Endocannabinoid signaling is critical for habit formation

open access: yesFrontiers in Integrative Neuroscience, 2007
Extended training can induce a shift in behavioral control from goal-directed actions, which are governed by action-outcome contingencies and sensitive to change in the expected value of the outcome, to habits which are less dependent on action-outcome ...
Monica R. F Hilário   +3 more
doaj   +1 more source

Human Neural Stem Cell Induced Functional Network Stabilization After Cortical Stroke: A Longitudinal Resting-State fMRI Study in Mice

open access: yesFrontiers in Cellular Neuroscience, 2020
Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes.
Anuka Minassian   +13 more
doaj   +1 more source

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

open access: yesScience, 2009
Techniques for systematically monitoring protein translation have lagged far behind methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling strategy that is based on the deep sequencing of ribosome-protected mRNA ...
Nicholas T. Ingolia   +3 more
semanticscholar   +1 more source

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