Results 221 to 230 of about 117,901,213 (253)

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

From raw material to functional food: Effect of dry-heat treatment on whole quinoa flour structure and dough rheology, with in vivo hypoglycemic validation at the optimal temperature. [PDF]

Food Chem X
Zhou YL, Li XL, You XY, Wang XY.
europepmc   +1 more source

Effects of an Essential Oil Blend on In Vitro Methane Production, In Vitro and In Vivo Nutrient Digestibility, Growth Performance, and Meat Quality in Lithuanian Blackface Lambs. [PDF]

Animals (Basel)
Lileikis T, Razmaitė V, Uchockis V, Bliznikas S.   +3 more
europepmc   +1 more source

Synergistic effects of <em>Leucaena leucocephala</em>-ginger phytogenic pellet on rumen fermentation, microbial protein synthesis, and enteric methane mitigation in Thai native beef cattle. [PDF]

Vet World
Wadjeam P, Phesatcha K, Matra M, Ampapon T, Phesatcha B.   +4 more
europepmc   +1 more source

Can Seaweed Be a Sustainable, One Health Resource in Livestock and Poultry Diets? [PDF]

Animals (Basel)
Shurson GC.
europepmc   +1 more source

Tropical legume grass forage (<i>Stylosanthes hamata</i> L.) reduces enteric methane yield and intensity and improves milk yield in Fulani zebu suckler cows. [PDF]

Vet Anim Sci
Gbenou GX, Orounladji BM, Adama B, Sanou F, Bastianelli D, Sib O, Sanogo S, Bonnal L, Vall E, Dossa LH, Assouma MH.   +10 more
europepmc   +1 more source