Results 231 to 240 of about 1,311,826 (266)

In Vivo Rat Model of Preeclampsia

2006
Preeclampsia is characterized by the clinical triad of new hypertension, proteinuria, and edema after 20 wk of gestation. Recent evidence suggests that disturbances in angiogenic factors (such as vascular endothelial growth factor and placental growth factor) signaling and endothelial health may play a major role in the pathogenesis of preeclampsia ...
S Ananth, Karumanchi, Isaac E, Stillman
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In vivo models of proliferative vitreoretinopathy

Nature Protocols, 2007
We outline current in vitro and in vivo models for experimental proliferative vitreoretinopathy (PVR) and provide a detailed protocol of our standardized in vivo PVR model. PVR is the leading cause of failed surgical procedures for the correction of rhegmatogenous retinal detachment.
Rajat N, Agrawal, Shikun, He, Christine, Spee, Jing Z, Cui, Stephen J, Ryan, David R, Hinton   +5 more
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In Vivo Models of Mechanical Loading

The skeleton fulfills its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modeled in response to changes in mechanical strains engendered by load-bearing.
Dionysia, Valkani, Lucinda A E, Evans, Andrew A, Pitsillides   +2 more
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In Vivo Modeling for Glucose Homeostasis

IEEE Transactions on Biomedical Engineering, 1975
A model for the glucose-insulin control system has been developed. The primary controllers in this model are the pancreas and liver. These subsystems operate within the metabolic environment to maintain normal glucose levels. The prime control variables for each subsystem, as well as for systemic glucose utilization, are the plasma glucose and insulin ...
S M, Finkelstein, M A, Bleicher, S, Batthany, J, Tiefenbrun   +3 more
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Generating an Ex Vivo Vascular Model

ASAIO Journal, 2005
Realistic ex vivo anthropometric vascular environments are required for endovascular device optimization and for preclinical evaluation of interventional procedures. The objective of this research is to build an anthropomorphic model of the human carotid artery.
O??Flynn, Padraig M., Roche, Ellen T., Pandit, Abhay S.   +2 more
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In Vitro and In Vivo Models of Multiple Sclerosis

CNS & Neurological Disorders - Drug Targets, 2012
Multiple sclerosis (MS) is widely considered to be the result of an aggressive autoreactive T cell attack on myelin. How these autoimmune responses arise in MS is unclear, but they could result from virus infections. Thus, viral and autoimmune diseases in animals have been used to investigate the possible pathogenic mechanisms operating in MS.
van der Star, B.J., Vogel, D.Y.S., Kipp, M., Puentes, F., Baker, D., Amor, S.   +5 more
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In Vivo Models of Muscle Angiogenesis

2016
Angiogenesis is an important determinant of tissue function, from delivery of oxygen and other substrates to removal of waste products, in health and disease (e.g., adaptive or pathological remodelling). The phenotype and functional responses of endothelial cells are conditioned by systemic humoral signals and local environmental factors, including the
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In Vivo Models of Developmental Toxicology

2012
The founding principles of teratology/developmental toxicology state that a developmental toxicants cause dysmorphogenesis when conceptuses are exposed at a sufficient dosage during a sensitive period of development in a sensitive species. While in vitro approaches in developmental toxicology can provide a means to assess the potency of toxicants ...
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Predictive In Vivo Models for Oncology

2015
Experimental oncology research and preclinical drug development both substantially require specific, clinically relevant in vitro and in vivo tumor models. The increasing knowledge about the heterogeneity of cancer requested a substantial restructuring of the test systems for the different stages of development.
Diana, Behrens, Jana, Rolff, Jens, Hoffmann   +2 more
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An In Vivo Model of Recurrent Glioblastoma

Glioblastoma (GBM) is a highly aggressive and prevalent adult brain tumor. Despite an intensive standard of care consisting of surgical resection followed by radiation therapy and chemotherapy with temozolomide, patients invariably succumb to the recurrent tumor and face an overall survival of less than 15 months.
Muhammad Vaseem, Shaikh, Benjamin, Brakel, Alisha, Anand, Chitra, Venugopal, Sheila K, Singh   +4 more
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