Results 251 to 260 of about 1,321,319 (311)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models. [PDF]

open access: yesPharmaceuticals (Basel)
Steyn JD   +6 more
europepmc   +1 more source

TRPV1 Blocker, Peptide HCRG21 from Sea Anemone <i>Heteractis magnifica</i>, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models. [PDF]

open access: yesInt J Mol Sci
Klimovich A   +9 more
europepmc   +1 more source

Angiogenic growth factor-endothelial cell interaction: receptor binding and cell internalization techniques

open access: yes, 2003
BUGATTI, Antonella   +4 more
core  

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