Results 241 to 250 of about 132,203 (305)

Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Yahya Kanani, Ahmad Oryan, Abdollah Derakhshandeh   +2 more
wiley   +1 more source

Diagnostic Investigation of Two Cases of Oslerus osleri Infection in Dogs: Microscopic Challenges and Molecular Characterisation

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Two cases of young dogs with chronic cough were investigated, one with bronchoalveolar lavage for cytology, the other with endoscopic biopsy for histopathology. DNA was extracted from stained smears and from formalin paraffin‐embedded blocs, six primer pairs spanning the ribosomal RNA gene of O.
Jeremie Korchia, Vishnu Manikantan, Ashley K. McGrew, Christina M. Jeffries, Rebecca L. Makii, Kelly McCord, Sriveny Dangoudoubiyam   +6 more
wiley   +1 more source

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, Volume 117, Issue 5, Page 1260-1272, May 2026.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

Molecular Mechanism of Caspase‐8–Dependent Interleukin‐18 Activation in Pancreatic Cancer Cells Induced by 5‐Fluorouracil and Nutrient Starvation

Genes to Cells, Volume 31, Issue 3, May 2026.
Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino, Yuko Nariai, Takeshi Urano   +2 more
wiley   +1 more source

Burden of Influenza and Cost‐Effectiveness Analysis of Introduction of an Influenza Vaccination Programme Among Older Adults in India

Influenza and Other Respiratory Viruses, Volume 20, Issue 5, May 2026.
ABSTRACT Background In India, no publicly funded seasonal influenza immunization is ongoing, partly because cost‐effectiveness is yet to be established. We estimate the cost‐effectiveness and budgetary impact of introducing seasonal influenza vaccination among adults aged ≥ 60 years in India, a known high‐risk group. Methods Estimates of disease burden
Anand Krishnan, Aslesh Ottapura Prabhakaran, Kusum Shekhawat, Ismael R. Ortega‐Sanchez, Rakesh Kumar, Ritvik Amarchand, Prabu Rajkumar, Suman Kanungo, Sumit Dutt Bhardwaj, Giridara Gopal, Girish Kumar Chethrapilly Purushothaman, Varsha Potdar, Alok Kumar Chakrabarti, Radhika Gharpure, Avinash Choudekar, Kathryn E. Lafond, Lalit Dar, Siddhartha Saha, Kathrine R. Tan, Eduardo Azziz‐Baumgartner   +19 more
wiley   +1 more source

Risk of Spread of Megalocytivirus pagrus1 (Infectious Spleen and Kidney Necrosis Virus) From Frozen Fillets

Journal of Fish Diseases, Volume 49, Issue 5, May 2026.
ABSTRACT Infectious spleen and kidney necrosis virus (ISKNV) is a significant threat to global aquatic food security by causing large‐scale mortality in the aquaculture of tilapia (Oreochromis niloticus) and mandarin fish (Siniperca chuatsi). ISKNV is a genogroup of Megalocytivirus pagrus1, along with RSIV and TRBIV, and their recent listing as WOAH ...
Joy A. Becker, Paul M. Hick, Dorothea Megarani, Hannah Siler, Felipe Pierezan, Shannon N. Gray, Kuttichantran Subramaniam   +6 more
wiley   +1 more source

Vaccination Coverage and Factors Associated With Incomplete Vaccination Schedules in Children Under 5 in a Peripheral Area of the Federal District of Brazil

Public Health Nursing, Volume 43, Issue 3, Page 543-553, May/June 2026.
ABSTRACT Objective To estimate vaccination coverage (VC) and analyze the factors associated with the incomplete vaccination schedule (IVS) in children under 5 years of age in two Basic Health Units in the Federal District of Brazil. Design A cross‐sectional study.
Ivea Rayane Mendes Nicacio Viana, Henry Maia Peixoto   +1 more
wiley   +1 more source

Longitudinal Surveillance of Influenza A Virus Exposure in Wild Boars (Sus scrofa) in Spain (2015–2023): Serologic and Virologic Evidence of Subtype Infections and H5N1 Spillover Risk

Zoonoses and Public Health, Volume 73, Issue 3, Page 191-204, May 2026.
ABSTRACT Introduction Influenza A viruses (IAVs) are responsible for respiratory infections in a wide range of species, including birds, swine and humans. The role of wild boar (Sus scrofa) in IAV epidemiology remains underexplored. Here, we present a longitudinal serologic and virologic surveillance study of wild boars in Spain from 2015 to 2023 ...
Paloma Encinas, Aitor Nogales, Estela Escribano‐Romero, M. Ángeles Martín del Burgo, Jorge Ramón López‐Olvera, José Enrique Granados, Gregorio Mentaberre, Adolfo García‐Sastre, Gustavo del Real   +8 more
wiley   +1 more source