Results 1 to 10 of about 2,682,884 (340)

Inborn Errors of Immunity and Cancer [PDF]

Biology, 2021
Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders characterized by a defect in the function of at least one, and often more, components of the immune system.
Alessandra Tiri, Riccardo Masetti, Francesca Conti, Anna Tignanelli, Elena Turrini, Patrizia Bertolini, Susanna Esposito, Andrea Pession   +7 more
doaj   +7 more sources

Neuroinflammation Associated With Inborn Errors of Immunity [PDF]

Frontiers in Immunology, 2022
The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial phenotypic heterogeneity.
Hannes Lindahl, Hannes Lindahl, Yenan T. Bryceson, Yenan T. Bryceson, Yenan T. Bryceson   +4 more
doaj   +8 more sources

Dendritic cells in inborn errors of immunity [PDF]

Frontiers in Immunology, 2023
Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They play critical role in homeostasis, inflammation, and autoimmunity.
Sudhir Gupta, Anshu Agrawal
doaj   +6 more sources

Granulomatous inflammation in inborn errors of immunity [PDF]

Frontiers in Pediatrics, 2023
Granulomas have been defined as inflammatory infiltrates formed by recruitment of macrophages and T cells. The three-dimensional spherical structure typically consists of a central core of tissue resident macrophages which may merge into multinucleated ...
Keith A. Sacco, Andrea Gazzin, Luigi D. Notarangelo, Ottavia M. Delmonte   +3 more
doaj   +5 more sources

Inborn errors of immunity (primary immunodeficiencies). [PDF]

Allergy Asthma Clin Immunol
Primary immunodeficiencies (PID), now often referred to as inborn errors of immunity (IEI), are a large heterogeneous group of disorders that result from deficiencies in immune system development and/or function.
Kim VHD, Upton JEM, Derfalvi B, Hildebrand KJ, McCusker C.   +4 more
europepmc   +3 more sources

Nature and nurture: understanding phenotypic variation in inborn errors of immunity [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
The overall disease burden of pediatric infection is high, with widely varying clinical outcomes including death. Among the most vulnerable children, those with inborn errors of immunity, reduced penetrance and variable expressivity are common but poorly
Morgan Similuk, Taco Kuijpers
doaj   +3 more sources

Human inborn errors of immunity associated with IRF4 [PDF]

Frontiers in Immunology, 2023
The transcription factor interferon regulatory factor 4 (IRF4) belongs to the IRF family and has several important functions for the adaptive immune response.
Romane Thouenon, Romane Thouenon, Sven Kracker, Sven Kracker   +3 more
doaj   +3 more sources

EBMT/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity [PDF]

, 2021
Transplantation and ...
Albert, M.H., Booth, C., European Reference Network Rare Pr, European Soc Blood Marrow Transpla, European Soc Immune Deficiencies, Gennery, A.R., Gungor, T., Honig, M., Lankester, A.C., Morris, E.C., Moshous, D., Neven, B., Schulz, A., Slatter, M., Veys, P.   +14 more
core   +4 more sources

Inborn errors of immunity to infection: the rule rather than the exception [PDF]

, 2005
The immune system's function is to protect against microorganisms, but infection is nonetheless the most frequent cause of death in human history. Until the last century, life expectancy was only ∼25 years.
Abel, Laurent, Casanova, Jean-Laurent
core   +3 more sources

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. [PDF]

, 2020
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19).
Abel, Laurent, Al Turki, Saeed, Al-Muhsen, Saleh Zaid, Al-Mulla, Fahd, Al-Saud, Haya, Alba, Camille, Almourfi, Feras, Alosaimi, Mohammed F., Alsohime, Fahad, Amara, Ali, Amsterdam UMC Covid-19, [missing], Arias, Andrés Augusto, Bastard, Paul, Bettini, Laura Rachele, Bigio, Benedetta, Bilguvar, Kaya, Biobank, [missing], Biondi, Andrea, Bizien, Lucy, Boisson, Bertrand, Boisson-Dupuis, Stéphanie, Bolze, Alexandre, Bonfanti, Paolo, Bonnet-Madin, Lucie, Bosteels, Cedric, Bustamante, Jacinta, Béziat, Vivien, Casanova, Jean-Laurent, Chbihi, Marwa, Chen, Jie, Ciancanelli, Michael, Cobat, Aurélie, Colobran, Roger, Corneau, Aurélien, CoV-Contact Cohort, [missing], COVID Clinicians, [missing], COVID Human Genetic Effort, [missing], COVID-STORM Clinicians, [missing], Dalgard, Clifton L., Dorgham, Karim, Duffy, Darragh, Duval, Xavier, D’Angio, Mariella, Fellay, Jacques, French COVID Cohort Study Group, [missing], Gallego, Carlos Rodríguez, García-Sastre, Adolfo, Goffard, Jean-Christophe, Gorochov, Guy, Haerynck, Filomeen, Han, Ji Eun, Hasanato, Rana, Hodeib, Stephanie, Hoffmann, Hans-Heinrich, Hoste, Eric, Hoste, Levi, Hraiech, Sami, Imagine COVID Group, [missing], Imberti, Luisa, Jouanguy, Emmanuelle, Karabela, Şemsi Nur, Karpf, Léa, Keles, Sevgi, Kerner, Gaspard, Khan, Taushif, Korniotis, Sarantis, Korol, Cecilia, Krammer, Florian, Laouénan, Cédric, Le Pen, Jérémie, Le Voyer, Tom, Li, Juan, Lifton, Richard, Liu, Zhiyong, Lorenzo, Lazaro, Maniatis, Tom, Manry, Jeremy, Mansouri, Davood, Marr, Nico, Martin-Nalda, Andrea, Masson, Cecile, Meade, Philip, Meyts, Isabelle, Michailidis, Eleftherios, Migeotte, Isabelle, Milner, Joshua, Moens, Leen, Mogensen, Trine H., Moncada-Velez, Marcela, Morange, Pierre-Emmanuel, Naesens, Leslie, Neehus, Anna-Lena, NIAID-USUHS, [missing], Notarangelo, Luigi D., Novelli, Giuseppe, Nussenzweig, Michel, Ogishi, Masato, Oler, Andrew J., Onodi, Fanny, Ozcelik, Tayfun, Paghera, Simone, Philippot, Quentin, Puel, Anne, Pujol, Aurora, Quiros-Roldan, Eugenia, Rapaport, Franck, Razooky, Brandon S., Rice, Charles M., Rosain, Jérémie, Rossi, Camillo, Roussel, Lucie, Sabli, Ira K. D., Sancho-Shimizu, Vanessa, Schlüter, Agatha, Schmitt, Yohann, Schneider, William M., Seeleuthner, Yoann, Senoglu, Sevtap, Shahrooei, Mohammad, Smith, Nikaïa, Smits, Guillaume, Snow, Andrew L., Soler-Palacin, Pere, Sottini, Alessandra, Soumelis, Vassili, Spaan, András N., Su, Helen C., TAGC COVID Immunity Group, [missing], Tandjaoui-Lambiotte, Yacine, Tavernier, Simon, Tompkins, Miranda F., Ugurbil, Aileen Camille, Van Braeckel, Eva, van de Beek, Diederik, Van Praet, Jens, Vandernoot, Isabelle, Vinh, Donald C., Yang, Rui, Yasar, Kadriye Kart, Ye, Junqiang, Zhang, Peng, Zhang, Qian, Zhang, Shen-Ying, Zhang, Yu, Zhou, Qinhua, Çölkesen, Fatma   +145 more
core   +10 more sources