Results 141 to 150 of about 15,568 (286)

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, EarlyView.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Biotin Status of Epileptics [PDF]

, 1985
Achuta Murthy P. N., Berlit P., Blass J. P., Bonjour J.-P., Bonjour J.-P., Caspers H., Frigg M., Ghatak N. R., Glaser G. H., Iivanainen M., Johnston D., Krause K.-H., Krause K.-H., Krause K.-H., Meinardi H., Mock D. M., Munoz-Garcia D., Noll F., Patel M. S., Paulsen E. P., Reynolds E. H., Sander J. E., Schmidt D., Scorn D., Selhorst J. B., Sweetman L., Sydenstricker V. P., Thoene J., Vivo D. C., Watanabe T., Wolf B., Woodbury D. M., Woodbury D. M., Woodbury D. M.   +33 more
core   +1 more source

Evaluation of a Clinical Risk Score for Preterm Necrotising Enterocolitis: The ‘Check‐NEC Score’

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background and Aim Early prediction of necrotising enterocolitis (NEC) in preterm infants is important given its significant health, economic and social–emotional burden. We aimed to validate a clinical risk score (Check‐NEC Score [CNS]) for this purpose in preterm infants.
Tiara Davis, Chandra Rath, Gayatri Athalye‐Jape, Elizabeth Nathan, Jeffrey Keelan, Sanjay Patole   +5 more
wiley   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Association Between Perioperative Sleep Disorders and Post‐Operative Delirium in Cardiac Surgeries: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
Overview of studies included in the systematic review investigating the association between perioperative sleep disorders (PSD) and postoperative delirium (POD) in patients undergoing cardiac surgery. ABSTRACT Post‐operative delirium (POD) is an acute deterioration in cognitive function and highly prevalent after cardiac surgery (CS; up to 55 ...
Hesam Varpaei, Pallav Deka, Lorraine B. Robbins, Kousha Farhadi, Mathew Reeves, Fabrice Mowbray, Stuart F. Quan   +6 more
wiley   +1 more source

GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean

New Phytologist, EarlyView.
Summary Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N‐ethylmaleimide‐sensitive factor (NSF) attachment protein (α‐SNAP) – NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding.
Vinavi A. Gamage, Mariola Usovsky, Anser Mahmood, Elizabeth De Meyer, Bishnu Dhital, Clinton G. Meinhardt, Qijian Song, Lesa J. Beamer, Andrew M. Scaboo, Melissa G. Mitchum   +9 more
wiley   +1 more source

Correction to: Pre-Transplant Immune Dysregulation Predicts for Poor Outcome Following Allogeneic Haematopoietic Stem Cell Transplantation in Adolescents and Adults with Inborn Errors of Immunity (IEI) [PDF]

In the published version, there was an erratum in the abstract: - In the first sentence, the word “disease” was used twice: Incorrect: “Allogeneic haematopoietic stem cell transplantation (alloHSCT) is safe and effective for adolescents and adults with ...
Burns, Siobhan O, Carpenter, Ben, Fiaccadori, Valeria, Fox, Thomas A, Grace, Sarah, Hough, Rachael, Laurence, Arian, Lever, Charley, Lowe, David M, Massey, Valerie, Morris, Emma C, Oliviero, Filippo, Pearce, Rachel, Seidel, Markus G, Symes, Andrew, Tadros, Susan, Workman, Sarita   +16 more
core  

Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia

New Phytologist, EarlyView.
Summary Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the acclimation of Arabidopsis thaliana quantitative immune responses against the fungal pathogen Sclerotinia sclerotiorum to daily environmental ...
Marie Didelon, Justine Sucher, Florent Delplace, Pedro Carvalho‐Silva, Matilda Zaffuto, Adelin Barbacci, Sylvain Raffaele   +6 more
wiley   +1 more source

Gestational Diabetes Mellitus and Adverse Maternal and Neonatal Health Outcomes: an Umbrella review of Meta‐Analyses

Obesity Reviews, EarlyView.
ABSTRACT Introduction This study systematically synthesized evidence on adverse health outcomes related to gestational diabetes mellitus (GDM) via an umbrella review with integrated meta‐analyses. Methods The search covered publications from the database (PubMed/MEDLINE, Google Scholar, Embase, and CINAHL) inception to August 12, 2024. Meta‐analyses of
Jiseung Kang, Hyeon Jin Kim, Yeona Jo, Kathryn J. Smith, Arianna R. S. Lark, Fayaz A. Mir, Jaeyu Park, Hayeon Lee, Yumin Kim, Masoud Rahmati, Lee Smith, Sang Youl Rhee, Yejun Son, Dong Keon Yon, Christa J. Nehs   +14 more
wiley   +1 more source