Results 151 to 160 of about 7,598 (255)

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source

Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation. [PDF]

Immunol Res
Szczawińska-Popłonyk A.
europepmc   +1 more source

Prefrontal TRPM8 Receptor Modulates Epileptic Seizures via PKA/CREB Signaling Pathway in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Jia‐zhan Huang et al. describe a function of prefrontal TRPM8 in the regulation of epileptic seizures. TRPM8 receptors was upregulated in the prefrontal cortex (PFC) of epileptic mice. Inhibition or knockdown of TRPM8 in PFC can effectively prolong the latency and reduce the level of seizures in mouse models induced by pentatetrazole. At the same time,
Jia‐Zhan Huang, Gui‐Feng Lu, Yi‐Han Jiang, Yao Guo, Ze‐Yu Lin, Zhi Zhang, Fei Geng   +6 more
wiley   +1 more source

The prevalence of allergic manifestations in inborn errors of immunity: a retrospective cohort study. [PDF]

BMC Immunol
Esmaeilzadeh H, Esmaeilbeig M, Askarisarvestani A, Alyasin S, Nabavizadeh SH.   +4 more
europepmc   +1 more source

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization

European Journal of Immunology, Volume 56, Issue 1, January 2026.
Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double‐negative thymocyte proliferation and T‐cell production.
Betul Melike Ogan, Veronika Forstlova, Laura Jane Dowling, Michaela Simova, Kristina Vicikova, Vendula Novosadova, Frantisek Spoutil, Sylvie Cervenkova, Michaela Procházková, Jolana Tureckova, Olha Fedosieieva, Juraj Labaj, Petr Nickl, Kamila Krizova, Jan Prochazka, Radislav Sedlacek, Jana Balounova   +16 more
wiley   +1 more source

Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu, Jingjing Zhou, Pingwen Xu, Ishwari Gyawali, Chang Xu, Jinping Yang, Zewei Ma, Dan Du, Qingyan Jiang, Gang Shu   +9 more
wiley   +1 more source

Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity. [PDF]

J Clin Immunol
Segura-Tudela A, Nieto-López C, Bermejo-Olivera FJ, Andara LA, Arroyo-Ródenas J, Dueñas-Prieto L, Alfocea-Molina Á, Paz-Artal E, Pleguezuelo D, Cabrera-Marante O, Allende LM.   +10 more
europepmc   +1 more source

Clinical exome sequencing data from patients with inborn errors of immunity: cohort level meta-analysis and the benefit of systematic reanalysis [PDF]

Emil E. Vorsteveld, Caspar I. van der Made, Sanne P. Smeekens, Janneke Schuurs-Hoeijmakers, Galuh Astuti, Heleen Diepstra, Christian Gilissen, Evelien Hoenselaar, Alice Janssen, Kees van Roozendaal, Jettie Sikkema-van Engelen, Wouter Steyaert, Marjan M. Weiss, Helger G. Yntema, Tuomo Mantere, Mofareh AlZahrani, Koen van Aerde, Beáta Dérfalvi, Eissa Faqeih, Stefanie Henriet, Elise van Hoof, Eman Idressi, Thomas B. Issekutz, Marjolijn C.J. Jongmans, Riikka Keski-Filppula, Ingrid P.C. Krapels, D. Maroeska W. M. te Loo, Catharina M Mulders-Manders, Jaap ten Oever, Judith Potjewijd, Nora Tarig Sarhan, Marjan C. Slot, Pauline Terhal, Herman Thijs, Anthony Vandersteen, Els K. Vanhoutte, Frank L. van de Veerdonk, Gijs Well, Mihai G. Netea, Annet Simons, Alexander Hoischen   +40 more
openalex   +1 more source

Rebalancing Hemostasis: Fitusiran as a First‐in‐Class RNAi Therapy in Hemophilia A and B

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Fitusiran is a first‐in‐class RNA interference (RNAi) therapy that lowers antithrombin (AT) to rebalance hemostasis in people with Hemophilia A or B, with or without inhibitors. Its recent FDA approval marks a major shift toward factor‐independent prophylaxis.
Raza Ur Rehman, Rida Fatima, Aymar Akilimali   +2 more
wiley   +1 more source

Toll-like Receptors in Inborn Errors of Immunity in Children: Diagnostic Potential and Therapeutic Frontiers-A Review of the Latest Data. [PDF]

Cells
Jurczuk A, Bałdyga P, Płoński A, Jurczuk M, Garley M.   +4 more
europepmc   +1 more source