Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility
Cadernos de Saúde Pública, 2002 Epidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered ...
Hatagima Ana
doaj
Journal of Traditional and Complementary Medicine, 2013 Excessive oxidative stress induced by reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive metabolites of carcinogens alters cellular homeostasis, leading to genetic/epigenetic changes, genomic instability, neoplastic ...
Jong Hun Lee +4 more
doaj +1 more source
Explanation for Cancer in Rats, Mice and Humans due to Cell Phone Radiofrequency Radiation [PDF]
arXiv, 2016 Very recently, the National Toxicology Program reported a correlation between exposure to whole body 900 MHz radiofrequency radiation and cancer in the brains and hearts of Sprague Dawley male rats. This paper proposes the following explanation for these results.
arxiv
Symmetric vs asymmetric stem cell divisions: an adaptation against cancer? [PDF]
, 2013 Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis.
arxiv +1 more source
Homogenization Model for Aberrant Crypt Foci [PDF]
arXiv, 2014 Several explanations can be found in the literature about the origin of colorectal cancer. There is however some agreement on the fact that the carcinogenic process is a result of several genetic mutations of normal cells. The colon epithelium is characterized by millions of invaginations, very small cavities, called crypts, where most of the cellular ...
arxiv
Self-Reported Chemicals Exposure, Beliefs About Disease Causation, and Risk of Breast Cancer in the Cape Cod Breast Cancer and Environment Study: A Case-Control Study [PDF]
, 2010 BACKGROUND: Household cleaning and pesticide products may contribute to breast cancer because many contain endocrine disrupting chemicals or mammary gland carcinogens.
Aschengrau, Ann +3 more
core +4 more sources
Mathematical control theory, the immune system, and cancer [PDF]
arXiv, 2016 Simple ideas, endowed from the mathematical theory of control, are used in order to analyze in general grounds the human immune system. The general principles are minimization of the pathogen load and economy of resources. They should constrain the parameters describing the immune system. In the simplest linear model, for example, where the response is
arxiv
Trends in bronchoscopic findings over a decade [PDF]
, 2009 The incidence of lung cancer in Maltese males is higher than that in females. However trends in Maltese and other foreign populations indicate a substantial recent increment in the diagnosis of lung cancer in women.
Agius, Maria +4 more
core
Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility
Cadernos de Saúde PúblicaEpidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered ...
Ana Hatagima
doaj +2 more sources
A Statistical Approach to Identifying Significant Transgenerational Methylation Changes [PDF]
arXiv, 2014 Epigenetic aberrations have profound effects on phenotypic output. Genome wide methylation alterations are inheritable to pass down the aberrations through multiple generations. We developed a statistical method, Genome-wide Identification of Significant Methylation Alteration, GISAIM, to study the significant transgenerational methylation changes ...
arxiv