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Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein
Frontiers in Microbiology, 2020 High level expression of recombinant proteins in bacteria often results in their aggregation into inclusion bodies. Formation of inclusion bodies poses a major bottleneck in high-throughput recovery of recombinant protein.
Anupam Singh +3 more
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Artificial Inclusion Bodies for Clinical Development
Advanced Science, 2020 Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials ...
Julieta M. Sánchez +11 more
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State-of-the-art and novel approaches to mild solubilization of inclusion bodies [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Throughout the twenty-first century, the view on inclusion bodies (IBs) has shifted from undesired by-products towards a targeted production strategy for recombinant proteins.
Robert Klausser +11 more
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Microbial Cell Factories, 2018 Background Physiological aggregation of a recombinant enzyme into enzymatically active inclusion bodies could be an excellent strategy to obtain immobilized enzymes for industrial biotransformation processes.
Romana Koszagova +7 more
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Morphogenesis and functional organization of viral inclusion bodies [PDF]
Cell Insight, 2023 Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, and ending with
Zhifei Li +4 more
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Two Cases of Feather Dystrophy in Free-Living Griffon Vultures (Gyps fulvus fulvus) Associated with Viral-like Inclusion Bodies [PDF]
AnimalsThe griffon vulture (Gyps fulvus fulvus) is a scavenger species that plays a vital ecological role in carrion removal. Successful survival and reproduction in captive and wildlife conditions require optimal physical status and plumage integrity ...
Stefano Pesaro +12 more
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Inclusion bodies: Not that bad… [PDF]
Frontiers in Microbiology, 2014 The formation of inclusion bodies constitute a frequent event during the production of heterologous proteins in bacterial hosts. Although the mechanisms leading to their formation are not completely understood, empirical data have been exploited trying ...
Ana eRamon +2 more
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Neurodegenerative disease-associated inclusion bodies are cleared by selective autophagy in budding yeast [PDF]
Autophagy Reports, 2023 Protein misfolding, aggregation, and accumulation cause neurodegenerative disorders. One such disorder, Huntington’s disease, is caused by an increased number of glutamine-encoding trinucleotide repeats CAG in the first exon of the huntingtin (HTT) gene.
Austin Folger +4 more
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Neuroserpin Inclusion Bodies in a FENIB Yeast Model [PDF]
Microorganisms, 2021 FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which leads to proteotoxicity ...
Valentina Vapore +9 more
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Coiled-Coil Based Inclusion Bodies and Their Potential Applications [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The production of recombinant proteins using microbial cell factories is frequently associated with the formation of inclusion bodies (IBs). These proteinaceous entities can be sometimes a reservoir of stable and active protein, might display good ...
Marcos Gil-Garcia, Salvador Ventura
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