Results 1 to 10 of about 118,473 (208)

Morphogenesis and functional organization of viral inclusion bodies

Cell Insight, 2023
Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, and ending with
Zhifei Li, Miaomiao Zheng, Zhicheng He, Yali Qin, Mingzhou Chen   +4 more
doaj   +3 more sources

Cytomegalovirus-associated esophageal ulcer in an immunocompetent infant: When should ganciclovir be administered? [PDF]

Korean Journal of Pediatrics, 2012
Cytomegalovirus (CMV)-associated esophageal ulcer is rare in immunocompetent infants. The presence of inclusion bodies and immunohistochemical staining for CMV in biopsy specimens obtained during esophagogastroduodenoscopy (EGD) indicate that such ulcers
Hyo-Jeong Jang, Ae Suk Kim, Jin-Bok Hwang   +2 more
doaj   +3 more sources

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections [PDF]

Cells, 2021
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication.
Olga Dolnik, Gesche K. Gerresheim, Nadine Biedenkopf   +2 more
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Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]

PLoS ONE, 2015
Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan, Jie Zhang, Hong Guo, Shicui Yan, Qingxiu Chen, Fuxian Zhang, Qin Fang   +6 more
doaj   +4 more sources

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

eLife, 2023
Viral inclusion bodies (IBs) commonly form during the replication of Ebola virus (EBOV) in infected cells, but their role in viral immune evasion has rarely been explored.
Lin Zhu, Jing Jin, Tingting Wang, Yong Hu, Hainan Liu, Ting Gao, Qincai Dong, Yanwen Jin, Ping Li, Zijing Liu, Yi Huang, Xuan Liu, Cheng Cao   +12 more
doaj   +3 more sources

Involvement of L polymerase and heat shock proteins in the biogenesis of viral circular RNAs derived from respiratory syncytial virus [PDF]

mBio
Circular RNAs (circRNAs) are new members of noncoding RNAs that have gained increased attention, and reports on viral circRNAs and their functions continue to emerge in recent years.
Mingzhen Lin, Shanshan Miao, Xinru Yang, Yezhenghong Qiu, Zesen Mai, Yao Xiao, Mengyuan Xie, Yulong Luo, Caiqi Ma, Jifang Liu, Zhaoyu Liu, Wenxia Yao   +11 more
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Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity [PDF]

Cell Communication and Signaling
Many viral proteins undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates known as viral inclusion bodies (VIBs), which are utilized for genome replication and virion assembly, thus serving as potential targets for antiviral ...
Chu Zhang, Zhen Lv, Weiwei Zeng, Yong-An Zhang, Jiagang Tu   +4 more
doaj   +2 more sources

Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication

iScience
Summary: Viral inclusion bodies (VIBs) are subcellular structures required for efficient viral replication. How type II grass carp reovirus (GCRV-II), the mainly prevalent strain, forms VIBs is unknown.
Chu Zhang, Hui Wu, Hao Feng, Yong-An Zhang, Jiagang Tu   +4 more
doaj   +3 more sources

Participation of host cell proteins in inclusion bodies of non-segmented RNA virus infected cells: a molecular insight [PDF]

Virology Journal
Negative-sense RNA viruses (NSVs) carrying a non-segmented genome encompass a broad group of viruses responsible for numerous human diseases such as rabies, mumps, measles, respiratory illness and encephalitis.
Sharmistha Sarkar, Kriti Kestur Biligiri, Nisha Vats, Shravanti Rampalli, Surajit Ganguly, Naveen Kumar, Debi Prasad Sarkar, Nirmal Kumar Ganguly, Nishi Raj Sharma   +8 more
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N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication

Frontiers in Cell and Developmental Biology, 2021
N6-methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV).
Fabian Figueroa, Alonso Vega-Gibson, Joseline Catrileo, Aracelly Gaete-Argel, Aracelly Gaete-Argel, Sebastian Riquelme-Barrios, Sebastian Riquelme-Barrios, Luis Antonio Alonso-Palomares, Luis Antonio Alonso-Palomares, Lorena I. Tapia, Lorena I. Tapia, Fernando Valiente-Echeverría, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Ricardo Soto-Rifo, Monica L. Acevedo   +15 more
doaj   +1 more source