Results 71 to 80 of about 38,732 (289)

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

mBio, 2020
Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which concentrate all the proteins of the polymerase complex as well as some cellular ...
Marie Galloux, Jennifer Risso-Ballester, Charles-Adrien Richard, Jenna Fix, Marie-Anne Rameix-Welti, Jean-François Eléouët   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Fatal dual infection of avian polyomavirus and psittacine beak and feather disease virus in Chile

Austral Journal of Veterinary Sciences, 2017
A 6 week old Plum-headed parakeet (Psittacula cyanocephala) from a private bird collection in the Metropolitan Region of Chile died after presenting depression, ataxia, tremors of the head, subcutaneous hemorrhage and delayed crop emptying.
Gisela A. González-Hein, Carlos M. González, Bernardo R. Huaracán   +2 more
doaj   +1 more source

Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. [PDF]

PLoS Pathogens, 2009
Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication compartments (RC) during the early stages of HSV-1 infection.
Christine M Livingston, Marius F Ifrim, Ann E Cowan, Sandra K Weller   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Inclusões intracitoplasmáticas hialinas na medular da adrenal de bovinos

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2011
Cytoplasmic inclusion bodies in adrenal medullary chromaffin cells have been described in various species including humans. These inclusions are believed to be related to certain infectious, toxic and neurodegenerative diseases.
L.P Mesquita, C.C Abreu, F Wouters, M.S Varaschin, P.S Bezerra Jr   +4 more
doaj   +1 more source

Selection and verification of antibodies against the cytoplasmic domain of M2 of influenza, a transmembrane protein

mAbs, 2020
Interactions between the cytoplasmic domains of viral transmembrane proteins and host machinery often determine the outcome of viral infection. The M2 protein of influenza A has been identified as a key player in autophagy-mediated viral replication ...
Nileena Velappan, Sofiya Micheva-Viteva, Samantha H. Adikari, Geoffrey S. Waldo, Antonietta M. Lillo, Andrew R.M. Bradbury   +5 more
doaj   +1 more source

New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution

Viruses, 2021
Background: Respiratory Syncytial Virus (RSV) is the major cause of severe acute respiratory tract illness in young children worldwide and a main pathogen for the elderly and immune-compromised people.
Maxence Frétaud, Delphyne Descamps, Daphné Laubreton, Marie-Anne Rameix-Welti, Jean-François Eléouët, Thibaut Larcher, Marie Galloux, Christelle Langevin   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression

, 2015
C.P. was supported by a Ph.D. studentshipfunded by the University of St. Andrews, School of Medicine. I.P. is supported by a Cancer Research UK (CRUK) Ph.D. studentship awarded to J.L.P. and S.R. I.G. and N.C.
Coleman, Nicholas, Roberts, David, Groves, Ian, Powis, Simon J, Roberts, Sally, Roberts, David C, Pentland, Ieisha, Parish, Joanna; id_orcid, Parish, Joanna L, Paris, Christian   +9 more
core   +1 more source