Results 51 to 60 of about 7,022,792 (370)
Microbial Cell Factories, 2018 BackgroundThe bacterium E. coli is a major host for recombinant protein production of non-glycosylated products. Depending on the expression strategy, the recombinant protein can be located intracellularly. In many cases the formation of inclusion bodies
C. Slouka +7 more
semanticscholar +1 more source
Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors [PDF]
, 2012 Background: The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insoluble neurotoxic deposits is still ...
Espargaró Colomé, Alba +4 more
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Hereditary inclusion-body myopathies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015 The term hereditary inclusion-body myopathies (HIBMs) defines a group of rare muscle disorders with autosomal recessive or dominant inheritance and presence of muscle fibers with rimmed vacuoles and collection of cytoplasmic or nuclear 15-21 nm diameter tubulofilaments as revealed by muscle biopsy.
Broccolini, Aldobrando +1 more
openaire +3 more sources
Cytomegalovirus-associated esophageal ulcer in an immunocompetent infant: When should ganciclovir be administered? [PDF]
, 2012 Cytomegalovirus (CMV)-associated esophageal ulcer is rare in immunocompetent infants. The presence of inclusion bodies and immunohistochemical staining for CMV in biopsy specimens obtained during esophagogastroduodenoscopy (EGD) indicate that such ulcers
Ae Suk Kim +11 more
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, 2016 Prometheus, the fifth film of the Alien franchise, maintains narrative connections to the original four films but the inclusion of new aliens—the Engineers—radically shifts the feminist politic of the series.
Williams, Tess
core +3 more sources
Efficient recovery of recombinant CRM197 expressed as inclusion bodies in E.coli
PLoS ONE, 2018 CRM197, which retains the same inflammatory and immune-stimulant properties as diphtheria toxin but with reduced toxicity, has been used as a safe carrier in conjugated vaccines. Expression of recombinant CRM197 in E.
A. Park +5 more
semanticscholar +1 more source
Solubilization of inclusion bodies: insights from explainable machine learning approaches
Frontiers in Chemical Engineering, 2023 We present explainable machine learning approaches for gaining deeper insights into the solubilization processes of inclusion bodies. The machine learning model with the highest prediction accuracy for the protein yield is further evaluated with regard ...
Cornelia Walther +12 more
doaj +1 more source
Gender Equality and Human Rights [PDF]
, 2015 The achievement of substantive equality is understood as having four dimensions: redressing disadvantage; countering stigma, prejudice, humiliation and violence; transforming social and institutional structures; and facilitating political participation ...
Beth Goldblatt, Sandra Fredman
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Pediatric Blood &Cancer, EarlyView.ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein +3 more
wiley +1 more source
Protein folding and the formation of inclusion bodies
浙江大学学报. 农业与生命科学版, 2004 Newly synthesized polypeptide chains must be folded and assembled into unique three-dimensional structures in order to become functionally active. In the folding process, many misfolded proteins maybe produced and thus accumulate as aggregates.
JING Ming-yan, SUN Jian-yi
doaj +1 more source