Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Inclusive education: recipe book or quest. On diversity in the classroom and educational research [PDF]
, 2001 Yvonne Leeman, Monique Volman
openalex +2 more sources
Aid, Attitudes and Ambivalence: The Impact of Australian Aid in the Introduction and Sustainability of Inclusive Education Initiatives in the Republic of Kiribati [PDF]
, 1905 Rodney Yates
openalex +1 more source
Inclusion and Integration on Special Education
Procedia - Social and Behavioral Sciences, 2015 Today, nearly 25 years after shifting from integration to inclusion in the theoretical approach in special education, we postulate two questions: what is exactly meant by integration and inclusion? And, still more important: how do they differ in practice?
Garro-Gil, N. (Nuria) +1 more
openaire +3 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Inclusive mathematics education [PDF]
Mathematics Education Research Journal, 2020 Gervasoni, Ann, Peter-Koop, Andrea
openaire +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
The Social Development of Children with Severe Learning Difficulties: A Case Study of an Inclusive Education Initiative Between Two Primary Schools in Oxfordshire, UK [PDF]
, 1999 Denise Dew‐Hughes, Sonia Blandford
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Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Dyadic Training of Communication Partners for Autistic Students: A Feasibility Study
DisabilitiesAccess to communication is a primary challenge affecting the education of Autistic students who use augmentative and alternative communication devices.
Eric J. Anderson +2 more
doaj +1 more source