Results 101 to 110 of about 36,304 (249)

Clinical efficacy and safety of linagliptin in patients with diabetes type 2

Медицинский совет, 2016
Treatment of diabetes mellitus type 2 (T2DM) is a serious challenge which forces to search for new approaches in order to improve the results of pharmacotherapy. Recent advances in diabetology pertain to incretin-directed therapies.
E. V. Biryukova, A. M. Mkrtumyan
doaj   +1 more source

Glucose lowering and anti-atherogenic effects of incretin-based therapies: GLP-1 analogues and DPP-4-inhibitors [PDF]

, 2009
BACKGROUND: Type 2 diabetes is a chronic, progressive disease with a multi-faceted pathophysiology. Beyond the known defects of insulin resistance and beta-cell insufficiency, derangement of incretin hormones normally produced from the gut wall in ...
Berneis, K, Rini, G B, Rizvi, A A, Rizzo, M, Spinas, G A   +4 more
core   +1 more source

A treat‐to‐target approach for obesity management: A post hoc analysis of the SURMOUNT‐5 trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Introduction With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat‐to‐target (TtT) thresholds for obesity to the outcome measures of SURMOUNT‐5, which randomised participants with obesity to tirzepatide or ...
Carel W. le Roux, Luca Busetto, Louis Aronne, Deborah Bade Horn, Georgios K. Dimitriadis, Beverly Falcon, Luis‐Emilio Garcia‐Perez, Elisa Gomez Valderas, Theresa Hunter Gibble, Cagri Senyucel, Julia P. Dunn   +10 more
wiley   +1 more source

Safety, feasibility, and dose‐dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof‐of‐concept studies

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The duodenum plays a central role in metabolic regulation, influencing insulin sensitivity, and glucose homeostasis. In type 2 diabetes (T2D), structural and functional abnormalities of the duodenal mucosa (“diabetic duodenopathy”) are increasingly recognized as contributors to insulin resistance and dysglycaemia.
David N. O'Neal, Adrian Sartoretto, Bronte A. Holt, Barham K. Abu Dayyeh, Rhys Vaughan, Georgina Cameron, Sujievvan Chandran, Alexander J. Thompson, Howard McCollister, Paul Severson, Andrew C. Storm, Lian Cunningham, Elif I. Ekinci   +12 more
wiley   +1 more source

Fasting GLP-1 Levels in Women with PCOS and CAH

Acta Medica Bulgarica
Polycystic ovarian syndrome (PCOS) is the most prevalent condition associated with increased androgens, but some rare diseases, e.g., congenital adrenal hyperplasia (CAH), should also be considered in the differential diagnosis of hyperandrogenemia.
Robeva R., Kirilov G., Elenkova A., Zacharieva S.   +3 more
doaj   +1 more source

Providing holistic care for patients with metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis: Key aspects of clinical assessment and how to develop individualised care plans for surveillance and interventions

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD), characterised by hepatic steatosis and metabolic dysfunction (i.e., obesity, type 2 diabetes, dyslipidaemia, and hypertension), is affecting over 30% of the adult population worldwide.
Lanlan Chen, Paul Horn, Frank Tacke
wiley   +1 more source

Serum Levels of Incretin Hormones – GLP-1 and GIP in Patients with Type 1 Diabetes Mellitus

Folia Medica, 2019
Background: The glucagon-like peptide-1 (GLP-1) and the glucose- dependent Insulinotropic peptide (GIP) are natural incretin hormones, which are secreted respectively by the L- and K-cells of the intestinal mucosa in response to the physiological ...
Stanchev Pavel E., Orbetzova Maria M., Terzieva Dora D., Davcheva Delyana, Iliev Dimitar A., Petrov Sava V., Koleva Daniela I., Nonchev Boyan I.   +7 more
doaj   +1 more source

Real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes: A multi‐site retrospective study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Despite the established efficacy of tirzepatide in randomised controlled trials, real‐world effectiveness data in Japanese patients remain limited. This study evaluated the real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes over 52 weeks.
Yusuke Minakata, Masaki Miura, Nobuhiro Nakatake, Masahiro Masuzawa   +3 more
wiley   +1 more source

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

Metabolic Comparison of One-Anastomosis Gastric Bypass, Single-Anastomosis Duodenal-Switch, Roux-en-Y Gastric Bypass, and Vertical Sleeve Gastrectomy in Rat [PDF]

, 2018
Background One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass ...
Arble, Deanna M., Bozadjieva, Nadajda, Evers, Simon S., Frikke-Schmidt, Henriette, Lewis, Alfor, Myronovych, Andriy, Seeley, Randy J., Toure, Mouhamadoul Habib   +7 more
core   +1 more source