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Incretins in obesity and diabetes
Annals of the New York Academy of Sciences, 2019AbstractIncretins are hormones secreted from enteroendocrine cells after nutrient intake that stimulate insulin secretion from β cells in a glucose‐dependent manner. Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the only two known incretins.
Chee W. Chia, Josephine M. Egan
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Vnitrni lekarstvi, 2007
Insulin secretion is greater after peroral challenge than after intravenous glucose administration due to so-called incretin effect. The major incretins are glucagon-like peptide 1 and glucose-dependent-insulinotropic peptide. Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress ...
J, Vrbíková, K, Vondra
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Insulin secretion is greater after peroral challenge than after intravenous glucose administration due to so-called incretin effect. The major incretins are glucagon-like peptide 1 and glucose-dependent-insulinotropic peptide. Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress ...
J, Vrbíková, K, Vondra
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2010
WNT signaling is emerging as a global regulator of metabolism, targeting multiple tissues. This is achieved either directly through Wnt receptors, or indirectly through the action of incretins, hormones that enhance glucose-stimulated insulin secretion and target extrapancreatic organs that cooperatively control whole body energy balance. WNT increases
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WNT signaling is emerging as a global regulator of metabolism, targeting multiple tissues. This is achieved either directly through Wnt receptors, or indirectly through the action of incretins, hormones that enhance glucose-stimulated insulin secretion and target extrapancreatic organs that cooperatively control whole body energy balance. WNT increases
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1988
Publisher Summary This chapter provides an overview of incretin. According to LaBarre, incretin refers to endocrine factors from the gut with insulinotropic activity. An incretin should fulfill these conditions: (1) it must be released by nutrients, especially carbohydrates, (2) it must stimulate insulin secretion in the presence of elevated blood ...
W. Creutzfeldt, R. Ebert
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Publisher Summary This chapter provides an overview of incretin. According to LaBarre, incretin refers to endocrine factors from the gut with insulinotropic activity. An incretin should fulfill these conditions: (1) it must be released by nutrients, especially carbohydrates, (2) it must stimulate insulin secretion in the presence of elevated blood ...
W. Creutzfeldt, R. Ebert
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[The concept of incretins and the physiological roles of incretins].
Nihon rinsho. Japanese journal of clinical medicine, 2011Incretins, exemplified by glucagon-like peptide 1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. Both GLP-1 and GIP also promote beta cell proliferation and inhibit apoptosis, leading to expansion of beta cell mass. GLP-1, but not GIP, controls
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Journal of Medicine and Pharmacy, 2011
The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes so drugs acting on incretins may improve glycaemic control. Incretins are metabolised by dipeptidyl peptidase, so selectively inhibiting this enzyme increases the ...
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The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes so drugs acting on incretins may improve glycaemic control. Incretins are metabolised by dipeptidyl peptidase, so selectively inhibiting this enzyme increases the ...
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The expanding incretin universe: from basic biology to clinical translation
Diabetologia, 2023Daniel J Drucker +2 more
exaly