BioMed Research International, Volume 2021, Issue 1, 2021., 2021 The mobile colistin resistance (mcr) gene threatens the efficacy of colistin (COL), a last‐line antibiotic used in treating deadly infections. For more than six decades, COL is used in livestock around the globe, including Africa. The use of critically important antimicrobial agents, like COL, is largely unregulated in Africa, and many other factors ...
Madubuike Umunna Anyanwu +4 more
wiley +1 more source
Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa [PDF]
, 2016 A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones.
Brink, Adrian +5 more
core +1 more source
Scientific Reports, 2023 In this study, genomic and plasmid characteristics of Escherichia coli were determined with the aim of deducing how mcr genes may have spread on a colistin withdrawn pig farm. Whole genome hybrid sequencing was applied to six mcr-positive E. coli (MCRPE)
Nwai Oo Khine +4 more
doaj +1 more source
mcr-Colistin resistance genes mobilized by IncX4, IncHI2, and IncI2 plasmids in Escherichia coli of pigs and white stork in Spain [PDF]
, 2020 Colistin has become the last-line antimicrobial for the treatment of multidrug resistant (MDR) Enterobacterales in human medicine. To date, several colistin resistance genes have been described. Of them mcr-1 is disseminated worldwide in Escherichia coli
Aguirre Sánchez, J. R. +8 more
core +5 more sources
Fitness Advantage of mcr-1–Bearing IncI2 and IncX4 Plasmids in Vitro
Frontiers in Microbiology, 2018 The objective of this study was to assess the impact of diverse plasmids bearing colistin resistance gene mcr-1 on host fitness. Forty-seven commensal E.
Renjie Wu +8 more
doaj +1 more source
Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018) [PDF]
, 2019 Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat.
Elbediwi, Mohammed +10 more
core +1 more source
Complete Sequence of pSAM7, an IncX4 Plasmid Carrying a Novel bla[sub]CTX-M-14b Transposition Unit Isolated from ' Escherichia coli ' and ' Enterobacter cloacae ' from cattle [PDF]
, 2013 The same plasmid carrying blaCTX-M-14b was identified from an Escherichia coli isolate and an Enterobacter cloacae isolate collected from cattle in the United Kingdom by complete plasmid sequencing.
AbuOun, M. +7 more
core +2 more sources
Genetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 Acquisition
Scientific Reports, 2017 IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates.
Jian Sun +9 more
doaj +1 more source
Pathogens, 2021 The global dissemination of plasmid-mediated colistin resistance gene mcr and its variants have posed a great threat to public health. Therefore, the Chinese government banned the use of colistin as a feed additive in livestock in April 2017.
Zunfang Tu +5 more
doaj +1 more source
Escenario actual de la resistencia a la colistina mediada por plásmidos en América Latina [PDF]
, 2019 Colistin resistance can occur by chromosomal mutations and by acquisition of plasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburst of this resistance gene in our region. Due to the risk of the rapid dissemination
Di Conza, José Alejandro +2 more
core +1 more source