Results 41 to 50 of about 1,672 (143)

Emergence of IncX4 plasmids encoding mcr-1 in a clinical isolate of Klebsiella pneumoniae in Japan

International Journal of Infectious Diseases, 2018
The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli ...
Tatsuya Tada, Kohei Uechi, Isamu Nakasone, Masashi Nakamatsu, Kazuhito Satou, Takashi Hirano, Teruo Kirikae, Jiro Fujita   +7 more
doaj   +1 more source

Molecular characterization of extended-spectrum ß-lactamase producers, carbapenemase producers, polymyxin-resistant, and fosfomycin-resistant Enterobacterales among pigs from Egypt

Journal of Global Antimicrobial Resistance, 2022
Objectives: To perform the first prospective surveillance evaluating the occurrence of genes encoding colistin resistance, fosfomycin resistance, carbapenemase, or extended-spectrum ß-lactamases (ESBLs) among Enterobacterial isolates recovered from the ...
Mustafa Sadek, José Manuel Ortiz de la Rosa, Mustafa Ramadan, Patrice Nordmann, Laurent Poirel   +4 more
doaj   +1 more source

Co-production of MCR-1 and extended-spectrum β-lactamase in Escherichia coli recovered from urinary tract infections in Switzerland [PDF]

, 2017
International ...
Clerc, Olivier, Kieffer, Nicolas, Lienhard, Reto, Nordmann, Patrice, Poirel, Laurent   +4 more
core   +3 more sources

Prevalence and zoonotic transmission of colistin-resistant and carbapenemase-producing Enterobacterales on German pig farms [PDF]

, 2021
The treatment of infections due to colistin-resistant (Col-E) and carbapenemase-producing (CPE) Enterobacterales challenges clinicians both in human and veterinary medicine.
Boelhauve, Marc, Cuny, Christiane, Effelsberg, Natalie, Hofmann, Franka, Kobusch, Iris, Köck, Robin, Linnemann, Sabrina, Mellmann, Alexander, Schollenbruch, Hannah   +8 more
core   +1 more source

Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China

Microbiology Spectrum, 2023
Colistin is one of the last-resort antibiotics for treating infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, mcr genes conferring resistance to colistin have been widely identified, which is considered a global threat to ...
Xiaoyu Lu, Pei Zhang, Pengcheng Du, Xiuli Zhang, Juan Wang, Yingying Yang, Honghu Sun, Zhiqiang Wang, Shenghui Cui, Ruichao Li, Li Bai   +10 more
doaj   +1 more source

Coexistence of blaKPC-2–IncN and mcr-1–IncX4 plasmids in a ST48 Escherichia coli strain in China

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to explore the genomic content of a blaKPC-2- and mcr-1-harbouring Escherichia coli strain and to clarify the molecular mechanism for the transmission of multidrug resistance.
Yanfei Wang, Haiyang Liu, Qian Wang, Xiaoxing Du, Yunsong Yu, Yan Jiang   +5 more
doaj   +1 more source

Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1 -positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study [PDF]

, 2017
Background The mcr-1 gene confers transferable colistin resistance. mcr-1-positive Enterobacteriaceae (MCRPE) have attracted substantial medical, media, and political attention; however, so far studies have not addressed their clinical impact. Herein, we
Doi, Yohei, Fang, Ying, Huang, Xi, Lei, Lei, Li, Hong-Yu, Liu, Jian-Hua, Ren, Hongwei, Shen, Jianzhong, Shen, Yingbo, Shen, Zhangqi, Tian, Guo-Bao, Tyrrell, Jonathan M., Walsh, Timothy R., Wang, Shaolin, Wang, Yang, Wu, Congming, Zeng, Kun-Jiao, Zhang, Rong, Zhong, Lan-Lan, Zhou, Hongwei   +19 more
core   +2 more sources

Colistin resistance in monophasic isolates of Salmonella enterica ST34 collected from meat-derived products in Spain, with or without CMY-2 Co-production [PDF]

, 2022
This research was supported by project FIS PI17/00474 of the “Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad,” Spain, cofunded by European Regional Development Fund of the European Union: a ...
Bances, M., de Toro, M., Fernández, Javier, García, Vanesa, Ladero Losada, Víctor Manuel, Rodicio Rodicio, María del Rosario, Rodicio Rodicio, María Rosaura, Vázquez Sánchez, Xenia   +7 more
core   +1 more source

Dissemination and Comparison of Genetic Determinants of mcr-Mediated Colistin Resistance in Enterobacteriaceae via Retailed Raw Meat Products

Frontiers in Microbiology, 2019
The global food chain may significantly promote the dissemination of bacteria resistant to antibiotics around the world. This study was aimed at determining the prevalence and genetic characteristics of Enterobacteriaceae with mcr-mediated colistin (CT ...
Tereza Gelbíčová, Alžběta Baráková, Alžběta Baráková, Martina Florianová, Ivana Jamborová, Markéta Zelendová, Markéta Zelendová, Lucie Pospíšilová, Ivana Koláčková, Renáta Karpíšková   +9 more
doaj   +1 more source

Expansion of KPC-producing klebsiella pneumoniae with various mgrB-mutations giving rise to colistin-resistance:the role of ISL3 on plasmids [PDF]

, 2018
BACKGROUND: mcr-1 has been reported as first plasmid gene to confer colistin-resistance. In KPC-producing Klebsiella pneumoniae (KPC-KP) isolates, however, colistin resistance is rapidly emerging through other mechanisms. This is frequently the result of
Barnini, Simona, Bathoorn, Erik, Chlebowicz, Monika A, Friedrich, Alexander W, Gikas, Achilleas, Giordano, Cesira, Rossen, John W, Scoulica, Effie V, Tsioutis, Constantinos   +8 more
core   +1 more source