Results 141 to 150 of about 16,633,437 (341)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2022 Helical milling is one of the high-performance and high-quality hole manufacturing activities with strong prospects for the automotive and aerospace industries. Literature suggests chip geometry plays a significant role in optimizing machining operations.
P., Satish Kumar +2 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Import and export process: the impact of bureaucratic simplification in customs clearance
, 2022 The procedures for importing and exporting merchandise in Brazil involve many bureaucratic matters, including federal and international laws. When something overseas arrives, along with its property certificate documents, the owner or company should ...
Castañeda-Ayarza, Juan Arturo +1 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
This report synthesizes the findings of a workshop, held by Oregon’s Independent Multidisciplinary Science Team (IMST) in January, 2015, to discuss state-level science review and how to best formulate a panel to conduct scientific review of a broad suite
Independent Multidisciplinary Science Team
core +1 more source
, 2020 The vehicle-routing problem (VRP) combined with freight-loading problem is a complex and relatively recent issue studied by the scientific literature. This paper presents the formulation of a mathematical model and a procedure to solve this problem in a ...
Frómeta Moya, Jorge Israel +3 more
core +1 more source
The Impact of Taxes on the Reproduction of Natural Forest Resources in Ukraine
, 2021 The research was directed to confirming or disproving the hypothesis that increasing tax pressure on the forest industry encourages the irrational use of forest resources to cover tax payments.
Fuhelo, Pavlina +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source