Results 91 to 100 of about 174,209,824 (205)

Data_Sheet_1_Microcirculation function assessment in acute myocardial infarction: A systematic review of microcirculatory resistance indices.pdf

, 2022
BackgroundUp to 50% of acute myocardial infarction (MI) patients present with microvascular dysfunction, after a successful percutaneous coronary intervention (PCI), which leads to worse clinical outcomes.
Marta Silva (1547365), Rogério Teixeira (3410468), Luis Paiva (7175234), Lino Gonçalves (5137163), Maria João Ferreira (2453842)   +4 more
core   +1 more source

Influence of the amount of myocardium subtended to a coronary stenosis on the index of microcirculatory resistance. Implications for the invasive assessment of microcirculatory function in ischaemic heart disease

EuroIntervention, 2017
The index of microcirculatory resistance (IMR) is increasingly used to quantify microcirculatory function. However, in normal coronary arteries, resistance increases with the branching structure of the coronary tree, which suggests that IMR could be influenced by the amount of downstream myocardial mass (MM).
Echavarría-Pinto, Mauro, van de Hoef, Tim P., Nijjer, Sukhjinder, Gonzalo, Nieves, Nombela-Franco, Luis, Ibañez, Borja, Sen, Sayan, Petraco, Ricardo, Jimenez-Quevedo, Pilar, Nuñez-Gil, Ivan J., Cerrato, Enrico, Salinas, Pablo, Quirós, Alicia, Garcia-Garcia, Hector M., Fernandez-Ortiz, Antonio, Macaya, Carlos, Davies, Justin, Piek, Jan, Escaned, Javier   +18 more
openaire   +3 more sources

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients

, 2019
Introduction Previous studies have suggested that high volume hemofiltration (HVHF) may contribute to revert hypotension in severe hyperdynamic septic shock patients.
Hernández P., Glenn, Ruiz, Carolina, Downey Concha, Patricio, Andresen Hernández, Max, Godoy, Cristián, Bruhn, Alejandro   +5 more
core   +1 more source

Implementation of Microcirculation Examination in Clinical Practice—Insights from the Nationwide POL-MKW Registry

Medicina
Background and Objectives: The assessment of coronary microcirculation may facilitate risk stratification and treatment adjustment. The aim of this study was to evaluate patients’ clinical presentation and treatment following coronary microcirculation ...
Rafał Januszek, Łukasz Kołtowski, Mariusz Tomaniak, Wojciech Wańha, Wojciech Wojakowski, Marek Grygier, Wojciech Siłka, Grzegorz Jan Horszczaruk, Bartosz Czarniak, Radosław Kręcki, Bartłomiej Guzik, Jacek Legutko, Tomasz Pawłowski, Paweł Wnęk, Marek Roik, Sylwia Sławek-Szmyt, Miłosz Jaguszewski, Tomasz Roleder, Miłosz Dziarmaga, Stanisław Bartuś   +19 more
doaj   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

Angiography-derived index of microcirculatory resistance (IMRangio) as a novel pressure-wire-free tool to assess coronary microvascular dysfunction in acute coronary syndromes and stable coronary artery disease

, 2021
To investigate the diagnostic accuracy of (1) hyperaemic angiography-derived index of microcirculatory resistance (IMRangio) in defining coronary microvascular dysfunction (CMD) across patients with acute coronary syndromes (ST-elevation myocardial ...
Roberto Scarsini, Hector M Garcia-Garcia, Mayooran Shanmuganathan, Keith M Channon, Giovanni Luigi De Maria, Alessandra Borlotti, Rafail A Kotronias, Vanessa M Ferreira, Jeremy P Langrish, Flavio Ribichini, Adrian P Banning, Dimitrios Terentes-Printzios, Andrew J Lucking, Hector M. Garcia-Garcia, Rafail A. Kotronias, Keith M. Channon, null null, Vanessa M. Ferreira, Adrian P. Banning, Jeremy P. Langrish, Andrew J. Lucking   +20 more
core   +1 more source

Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan‐Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction

Hepatology Research, EarlyView.
ABSTRACT Aim In Fontan‐associated liver disease (FALD), chronic congestion often confounds conventional fibrosis markers, complicating surveillance for hepatocellular carcinoma (HCC). Although lymphatic dysfunction is fundamental to Fontan physiology, its contribution to hepatocarcinogenesis remains unclear.
Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuuki Azuma, Tomonobu Hioki, Yusuke Morita, Keisuke Sakaguchi, Nobuhiro Fujita, Takamori Kakino, Ayako Ishikita, Kenichiro Yamamura, Ichiro Sakamoto, Kousei Ishigami, Kohtaro Abe, Yoshihiro Ogawa   +14 more
wiley   +1 more source

Application of a novel method for subsequent evaluation of sinusoids and postsinusoidal venules after ischemia-reperfusion injury of rat liver [PDF]

, 1998
Although several intravital fluorescence microscopic studies demonstrated that microcirculatory derangement is induced during liver ischemia-reperfusion, these data were obtained from randomly selected microvascular areas and microvessels, Repeated ...
Todoroki, T., Schildberg, Friedrich Wilhelm, Kondo, Tadashi, Okamoto, S., Messmer, K., Hirano, T.   +5 more
core   +1 more source

Characterizing Red Blood Cell Rheological Parameters Using Automated Syllectometry: Conventional and Exploratory Multivariate Analyses

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Red blood cell (RBC) biomechanics are key determinants of blood rheology, microcirculatory flow, and tissue oxygen delivery, yet remain underutilized in clinical practice because of methodological variability and limited standardization.
Baran Dastaran, Yousra Tera, Maica Jhiezl Yunon, Maha Othman   +3 more
wiley   +1 more source