Results 71 to 80 of about 174,209,824 (205)

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Impaired coronary flow reserve in patients with poor type 2 diabetes control: Preliminary results from prospective microvascular dysfunction registry

Cardiology Journal
BACKGROUND: Type 2 diabetes (DM) is a common comorbidity associated with cardiovascular disease, especially when poor glucose control is present. Extracardiac microcirculatory complications prevalence is well documented, however coronary microcirculatory
Łukasz Niewiara, Paweł Kleczyński, Bartłomiej Guzik, Piotr Szolc, Jakub Baran, Jakub Podolec, Marta Diachyshyn, Krzysztof Żmudka, Jacek Legutko   +8 more
doaj   +1 more source

Hemodynamic Significance of APEXCT Coronary Angiography Combined With Dynamic CT Myocardial Perfusion Imaging in Assessing Restenosis After Coronary Stenting

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to evaluate the hemodynamic significance of in‐stent restenosis (ISR) by using a combined anatomical‐functional approach with photon‐counting CT coronary angiography (APEX‐CT CTA) and dynamic CT myocardial perfusion imaging (CT‐MPI). We prospectively enrolled 239 symptomatic patients at least 9 months after PCI.
Liang‐Shi Wang, Tian Bai, Ji‐Zhou Yan, Peng‐Yu Guan, Li‐Juan Wen, Hong Guo, Tian‐Yu Zhang   +6 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Early Circulatory and Red Blood Cell Aggregation Changes During a Short‐Term Bone‐Specific Exercise Program in Community‐Dwelling Older Women: An Exploratory Pilot Study

Medicine Advances, EarlyView.
A 6‐week bone‐specific exercise program in community‐dwelling older women was associated with increased peripheral blood flow and improved red blood cell aggregation. In contrast, calcaneal quantitative ultrasound showed no significant change in the speed of sound.
Shiho Kurosaka, Nanoko Fujioka, Seiya Toyoshima, Takuma Yanaoka   +3 more
wiley   +1 more source

The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study

, 2017
AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI).
Alkhalil, M, Crea, F, Adrian Banning, Wolfrum, M, Dawkins S, Fahrni G, Mathias Wolfrum, Lisa Gaughran, Gaughran, L, Banning, AP, Sam Dawkins, Erica Dall’Armellina, Wolfrum M, Dall’Armellina, E, Keith Channon, Crea F, Alessandra Borlotti, Giovanni De Maria, Kharbanda, RK, Channon, KM, Langrish, JP, Borlotti, A, Andrew Lucking, De Maria GL, Choudhury RP, Banning AP, Choudhury, RP, Langrish JP, Porto I, Channon KM, Gregor Fahrni, Lucking, AJ, Fahrni, G, Dawkins, S, Filippo Crea, Borlotti A, Porto, I, Kharbanda RK, Jeremy Langrish, Gaughran L, Robin Choudhury, De Maria, GL, Alkhalil M, Italo Porto, Lucking AJ, Rajesh Kharbanda, Mohammad Alkhalil, Dall'Armellina E   +47 more
core   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Direct Stenting for Stable Angina Pectoris Is Associated With Reduced Periprocedural Microcirculatory Injury Compared With Stenting After Pre-Dilation

, 2008
Objectives: We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values.
Wyffels, E, Sarno, G, Bartunek, J, Sarma, J, Cuisset, T, Melikian, N, De Bruyne, B., Hamilos, M, Wijns, W, BARBATO, EMANUELE   +9 more
core   +1 more source

Timeline and flowchart of the study.

, 2023
Inclusion of the patients will be since April 2022 to June 2023. Analysis of biological samples and statistical analysis will be performed since July 2023 to December 2023.
Marcos Garcia-Guimaraes (8458002), Carlos Cortés Villar (15453573), Ferran Barbé (510961), Thalía Belmonte (6657887), Vicente Peral Disdier (13639951), Juan Casanova-Sandoval (13639927), Fernando Worner (3152415), Raúl Millán Segovia (15453576), Diego Fernández-Rodríguez (8077805), Ignacio Barriuso (13639930), Lucía Matute-Blanco (15453570), Kristian Rivera (8077808), Iván D. Benítez (11480363), David de Gonzalo-Calvo (11312838)   +13 more
core   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source