medflex: An R Package for Flexible Mediation Analysis using Natural Effect Models
Journal of Statistical Software, 2017 Mediation analysis is routinely adopted by researchers from a wide range of applied disciplines as a statistical tool to disentangle the causal pathways by which an exposure or treatment affects an outcome.
Johan Steen +3 more
doaj +1 more source
Interband Light Absorption at a Rough Interface
, 1999 Light absorption at the boundary of indirect-band-gap and direct-forbidden gap semiconductors is analyzed. It is found that the possibility of the electron momentum nonconservation at the interface leads to essential enhancement of absorption in porous ...
Ando +8 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Indirect Effects of Universal Infant Rotavirus Vaccination: A Narrative Systematic Review
VaccinesBackground/Objective: Rotavirus is a major cause of acute gastroenteritis (AGE) in children
Darren Suryawijaya Ong +3 more
doaj +1 more source
The Effects of Dividend Policy On the Price of Shares of Microfinance Companies In Developing Countries [PDF]
SocioEconomic ChallengesThe strategy of dividend policy implementation in the context of business value growth is the subject of debates in theoretical and empirical research.
Prem Bahadur Budhathoki, Kumar Khadka
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS
BioTech(1) Background: DNA damage is of great importance in the understanding of the effects of ionizing radiation. Various types of DNA damage can result from exposure to ionizing radiation, with clustered types considered the most important for ...
Ianik Plante +3 more
doaj +1 more source
The Stolper-Samuelson Theorem Reconsidered: An Example of Ricardian Dynamic Trade Effects [PDF]
Standard trade theory views the capital stock as an endowment. However, trade policy can affect a country's steady-state capital stock. By ignoring the endogeneity of capital, standard analysis is incomplete and can be misleading.
Richard E. Baldwin
core
How can the effects of the introduction of a new airline on a national airline network be measured? A time series approach for the Ryanair case in Spain [PDF]
, 2011 This paper quantifies the Ryanair Effect on the Spanish airline network. It proposes new methodology based on an advanced time series approach that allows both the direct and indirect effects of the incorporation of a new airline to be measured and ...
Castillo Manzano, José I. +2 more
core