Results 81 to 90 of about 2,702,302 (307)

Detecting cryptic indirect genetic effects.

Evolution; international journal of organic evolution, 2014
Research supported by NERC grants NE/G014906/1 & NE/I016937/1. APC paid through RCUK OA funds.
Bailey, Nathan William, Hoskins, Jessica L.   +1 more
openaire   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Territorial aggression and coexistence in hybridizing Campylorhynchus: disentangling the roles of climate, resource availability, and species interactions in western Ecuador

Journal of Avian Biology
Interspecific territoriality is a prevalent form of interference competition among animals across environments. However, the connections between interspecific territorial aggression and other related aspects such as hybridization and climate remain ...
Luis Daniel Montalvo, Rebecca T. Kimball, Scott K. Robinson   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

When Leaders Are Not Who They Appear: The Effects of Leader Disclosure of a Concealable Stigma on Follower Reactions [PDF]

, 2017
Two studies examined follower reactions to disclosure of concealable stigma (i.e., transgender identity) by a leader. Using 109 employed participants, Study 1 showed followers rated leaders disclosing a stigma less likable and effective.
Aguinis, Aguinis, Ashforth, Avery, Avolio, Barling, Bell, Brewer, Brodbeck, Buck, Buhrmester, Burke, Chrobot-Mason, Clair, Croteau, Den Hartog, DeRue, Dinh, Eagly, Eagly, Eagly, Efron, Epitropaki, Epitropaki, Epitropaki, Fassinger, Fingerhut, Gazzola, Goffman, Graen, Griffith, Haslam, Hayes, Hayes, Heilman, Heilman, Herek, Herek, Hill, Hogg, Hoyt, Hoyt, Johnson, Jones, Junker, Karelaia, Kark, King, King, King, King, Kite, Kite, Knippenberg, Kulik, Law, Lewicki, Liberman, Lidderdale, Lord, Lord, Lyness, MacInnis, Madera, Major, Mereish, Norton, Offermann, Oswald, Pachankis, Paetzold, Pescosolido, Pichler, Preacher, Preacher, Quaquebeke, Quaquebeke, Quinn, Ragins, Ragins, Reynolds, Rosette, Rothblum, Santuzzi, Sawyer, Schilt, Schmitt, Shamir, Shondrick, Sluss, Sluss, Tajfel, Tebbe, Tiedens, Winter, Yukl   +95 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Indirect effects of leadership behaviors on departmental performance via organizational learning in Ethiopian public research universities

Cogent Education
There are myriads of research outputs regarding the nexus between leadership behaviors and organizational effectiveness. Nonetheless, there is a scarcity of empirical studies examining the indirect effect of leadership behaviors on academic performance ...
Wakgari Tasisa Duressa, Befekadu Zeleke Kidane   +1 more
doaj   +1 more source

Study on character association in Lens culinaris medik.

Electronic Journal of Plant Breeding, 2021
A field trial with fifty genotypes of lentil was undertaken in Agriculture Farm of the Institute of Agriculture, Visva –Bharati University during two consecutive winters of the year 2017-18 and 2018-19, with an intention to find out the nature of the ...
Soumya Satpathy*, Sandip Debnath and Abinash Mishra
doaj   +1 more source

Effectiveness of conditional punishment for the evolution of public cooperation [PDF]

, 2013
Collective actions, from city marathons to labor strikes, are often mass-driven and subject to the snowball effect. Motivated by this, we study evolutionary advantages of conditional punishment in the spatial public goods game.
Arenas, Attila Szolnoki, Baldassarri, Bowles, Bowles, Boyd, Brandt, Brede, Chen, Clutton-Brock, de Quervain, Dornic, Dreber, Fehr, Fehr, Fort, Fowler, Fowler, García, Gracia-Lázaro, Gracia-Lázaro, Gächter, Gómez-Gardeñes, Gómez-Gardeñes, Hardin, Hauert, Hauert, Hauert, Helbing, Helbing, Henrich, Herrmann, Hilbe, Hilbe, Hrdy, Kodaka, Liggett, Lozano, Masuda, Mathew, Matjaž Perc, Mobilia, Nakamaru, Nowak, Ohtsuki, Panchanathan, Perc, Perc, Perc, Perc, Peña, Pinheiro, Rand, Rand, Rand, Requejo, Roca, Rockenbach, Santos, Santos, Santos, Sasaki, Semmann, Sigmund, Sigmund, Sigmund, Szabó, Szolnoki, Szolnoki, Szolnoki, Szolnoki, Szolnoki, Szolnoki, Szolnoki, Traulsen, Van Segbroeck, Vukov, Wakano, Wang, Wang, Wu, Wu, Zhang   +82 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source