Results 81 to 90 of about 2,682,331 (306)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal of Avian BiologyInterspecific territoriality is a prevalent form of interference competition among animals across environments. However, the connections between interspecific territorial aggression and other related aspects such as hybridization and climate remain ...
Luis Daniel Montalvo +2 more
doaj +1 more source
Direct and Indirect Effects of Public Infrastructure on Regional Economic Growth in Japan: An Application of the Covariance Structure Model by Geographical Classification Area [PDF]
The direct and indirect effects of public infrastructure (PI) were evaluated by a covariance structure model. Empirical results showed the positive indirect effect, crowding-in effect, as well as the direct effect as an input factor, differences of these
Kunimitsu, Yoji
core +1 more source
Approximate properties of the response of nonlinear dynamic systems to stochastic inputs [PDF]
, 1971 Indirect method considers effect of nonlinearity and obtains approximate probability densities of certain characteristics, from these densities various statistical properties are calculated. Direct method determines response moments directly.
Zirkle, L. D.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cogent EducationThere are myriads of research outputs regarding the nexus between leadership behaviors and organizational effectiveness. Nonetheless, there is a scarcity of empirical studies examining the indirect effect of leadership behaviors on academic performance ...
Wakgari Tasisa Duressa +1 more
doaj +1 more source
Study on character association in Lens culinaris medik.
Electronic Journal of Plant Breeding, 2021 A field trial with fifty genotypes of lentil was undertaken in Agriculture Farm of the Institute of Agriculture, Visva –Bharati University during two consecutive winters of the year 2017-18 and 2018-19, with an intention to find out the nature of the ...
Soumya Satpathy*, Sandip Debnath and Abinash Mishra
doaj +1 more source
Threshold levels and the realization of a group benefit [PDF]
This paper considers a voluntary contribution threshold game in which a group benefit is realized only if the number of contributors at least reaches a threshold level, and analyzes the effect of the threshold level on the likelihood that the group ...
Xiaopeng Xu
core
Neighborhood Dynamics and Price Effects of Superfund Site Clean-Up [PDF]
, 2005 This report uses census data to analyze the price effects of superfund site clean-up, inclusive of both direct price effects and indirect effects through clean-up's effect on neighborhood demographic transitions and reinvestment in the housing stock. FRC
Brett Baden +2 more
core +1 more source