Results 71 to 80 of about 2,266,638 (297)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Indirect Spectrophotometric Method for Determining Epicillin

Journal of AOAC INTERNATIONAL, 1986
Abstract A new UV spectrophotometric assay for determination of epicillin in capsules and plasma is reported. The method is based on the absorptivity of a degradation product obtained from the acidic hydrolysis of the antibiotic. The isolation, identification, individual capsule assays, composite assay, and recovery studies are described.
L J, Núñez-Vergara, A, Roa, J A, Squella, R V, González-Barbagelata   +3 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Description of 3 failed attempts to estimate the calcium equivalency of phytase for growth performance and tibia ash of broiler chickens when using graded dietary levels of limestone

Poultry Science
: Three broiler experiments were conducted to estimate the Ca equivalency of a novel phytase using direct and indirect methods. All 3 experiments employed 4 concentrations of limestone to create 4 reference diets, deficient in nonphytate P, with ...
Carrie L. Walk, Opeadura T. Osunbami, Olayiwola Adeola   +2 more
doaj   +1 more source

The assessment of drought tolerance of winter soft wheat samples by a direct and an indirect method

Зерновое хозяйство России, 2018
The assessment of drought tolerance of winter soft wheat samples by a direct and an indirect method The article presents the results of assessment of drought tolerance of winter soft wheat samples under stress conditions ‘zasushnik’, as well as the ...
V. L. Gaze, V. A. Likhovidova, E. V. Ionova   +2 more
doaj   +1 more source

Preliminary validation of an indirect method for discharge evaluation of Pertuso Spring (Central Italy) [PDF]

, 2016
This paper deals with the results of the first year of the Environmental Monitoring Plan, related to the catchment project of Pertuso Spring, which is going to be exploited to supply an important water network in the South part of Roma district.
De Filippi, F. M., Ferranti, Flavia, Sappa, Giuseppe   +2 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Production Costs Management by Means of Indirect Cost Allocated Model [PDF]

Management costs in a business system requires planning, budgeting, monitoring and comparing of all kinds of expenses. When calculating a production through the production order system there always seems to appear the same dilemma; which key or keys ...
Berislav Bolfek, Jasna Vujcic
core  

A system for the automatic measurement and digital display of systolic and diastolic blood pressures [PDF]

, 1971
Basic components of system are - occluding cuff with mounted cuff microscope, cuff pump deflator, pressure transducer, preamplifier unit, electrocardiograph machine, an analog to digital convertor unit, and digital display unit.
Schulze, A. E.
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source