Number needed to treat in indirect treatment comparison
Journal of Comparative Effectiveness Research, 2018 Aim: For dichotomous outcomes, odds ratio (OR) is one of the usual summary measures of indirect treatment comparison. A corresponding number needed to treat (NNT) estimate may facilitate understanding of the treatment effect. Methods: We show how to estimate NNT based on OR results of a matching adjusted
Patricia, Guyot +6 more
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Cancer Management and Research, 2018 Gabriel Tremblay,1 David Chandiwana,2 Mike Dolph,1 Jaclyn Hearnden,1 Anna Forsythe,1 Mauricio Monaco2 1Purple Squirrel Economics, New York, NY, USA; 2Novartis Pharmaceutical Corporation, East Hanover, NJ, USA Background: Ribociclib (RIBO) and palbociclib
Tremblay G +5 more
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Clinical Epidemiology, 2013 Eric Druyts,1 Kristian Thorlund,2,3 Samantha Humphreys,4 Michaela Lion,4 Curtis L Cooper,5 Edward J Mills1,31Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2Department of Clinical Epidemiology and Biostatistics, McMaster ...
Druyts E +5 more
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Indirect treatment comparison of iptacopan versus pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and residual anemia despite C5 inhibitor treatment [PDF]
Journal of Comparative Effectiveness ResearchThis study conducted an indirect treatment comparison (ITC) of iptacopan, the first oral monotherapy targeting factor B, versus pegcetacoplan, a subcutaneous infusion targeting complement component 3, in patients with paroxysmal nocturnal ...
Austin Kulasekararaj +9 more
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Indirect treatment comparison of oral sebetralstat and intravenous recombinant human C1 esterase inhibitor for on-demand treatment of hereditary angioedema attacks [PDF]
Allergy, Asthma & Clinical ImmunologyBackground The goal of on-demand treatment for hereditary angioedema attacks is to halt attack progression to minimize morbidity and mortality. Four on-demand treatments have been approved thus far (ecallantide, icatibant, recombinant human C1 esterase ...
H. Henry Li +11 more
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Dupilumab Versus Mepolizumab for COPD: Evaluating Efficacy Outcomes Using Placebo-Adjusted Indirect Treatment Comparison [PDF]
Pulmonary TherapyIntroduction Up to 40% of patients with chronic obstructive pulmonary disease (COPD) exhibit elevated blood eosinophils, reflective of type 2 inflammation.
Surya P. Bhatt +7 more
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Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison [PDF]
Trials, 2009 Background Comparing the effectiveness of interventions is now a requirement for regulatory approval in several countries. It also aids in clinical and public health decision-making.
Guyatt Gordon H +4 more
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Methods for Indirect Treatment Comparison: Results from a Systematic Literature Review [PDF]
Journal of Market Access & Health PolicyIntroduction: Health technology assessment (HTA) agencies express a clear preference for randomized controlled trials when assessing the comparative efficacy of two or more treatments.
Bérengère Macabeo +5 more
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Faricimab versus the standard of care for neovascular age-related macular degeneration in Italy: an indirect treatment comparison [PDF]
Drug Target InsightsObjectives: To assess through an indirect treatment comparison (ITC) the potential benefit of faricimab over the anti-vascular endothelial growth factor (VEGF) real-life scenario, hereby defined standard of care (SoC), in Italy, that is, aflibercept ...
Carlotta Galeone +7 more
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Indirect treatment comparison [PDF]
The Stata Journal: Promoting communications on statistics and Stata, 2014 This article presents a command, indirect, for the estimation of effects of multiple treatments in the absence of randomized controlled trials for direct comparisons of interventions.
Miladinovic, Branko +7 more
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