Results 31 to 40 of about 13,763,316 (290)

Indirect treatment comparison of cenobamate to other ASMs for the treatment of uncontrolled focal seizures [PDF]

Epilepsy & Behavior, 2022
The efficacy and safety of cenobamate relative to other antiseizure medications (ASMs) has not been evaluated. An indirect treatment comparison (network meta-analysis) was performed to determine if adjunctive cenobamate increases the odds ratio (OR) for ≥50% responder rate or for withdrawals due to treatment-emergent adverse events (TEAEs) leading to ...
Michael, Privitera, Florent F, Richy, Vernon F, Schabert   +2 more
openaire   +2 more sources

Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison [PDF]

, 2014
Objective: To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison.\ud Design: Systematic review ...
Cooper, N, H. Zheng (2057848), K. Merollini (7697756), Merollini, Katharina, Wilson, Jennie, Zheng, H, Berendt, T, Graves, Nicholas, Wilson, Jennie A., Nicola Cooper (698917), T. Berendt (7697759), Berendt, Tony, Zheng, Henry, Barnett, Adrian G., Sutton, A, Cooper, Nicola, J. Wilson (4917331), Barnett, A G, A. G. Barnett (7697753), Alex Sutton (11700), Graves, N, Wilson, J, N. Graves (7697762), Zhang, Henry, Sutton, Alex   +24 more
core   +2 more sources

A comparison of relative-efficacy estimate(s) derived from both matching-adjusted indirect comparisons and standard anchored indirect treatment comparisons

, 2023
ObjectivesWe present an empirical comparison of relative-efficacy estimate(s) from matching-adjusted indirect comparisons (MAICs) with estimates from corresponding standard anchored indirect treatment comparisons.MethodsA total of 80 comparisons were ...
Owen Cassidy (16963461), Joy Leahy (5467709), Arthur White (7179956), Marie Harte (14264624), Lea Trela-Larsen (4057561), Laura McCullagh (4723797), CATHAL WALSH (12347278)   +6 more
core   +1 more source

Simultaneous comparison of multiple treatments: combining direct and indirect evidence [PDF]

BMJ, 2005
How can policy makers decide which of five treatments is the best?
Caldwell, DM, Ades, AE, Higgins, JPT
openaire   +3 more sources

Arbitrated Indirect Treatment Comparisons

Therapeutic Innovation & Regulatory Science
Abstract Matching-adjusted indirect comparison (MAIC) has been increasingly employed in health technology assessments (HTA). By reweighting subjects from a trial with individual participant data (IPD) to match the covariate summary statistics of another trial with only aggregate data (AgD), MAIC facilitates the estimation of a treatment
Yixin Fang, Weili He
openaire   +4 more sources

Multiple treatment and indirect treatment comparisons: An overview of network meta-analysis

Perspectives in Clinical Research, 2014
Randomized control trials and its meta-analysis has occupied the pinnacle in levels of evidence available for research. However, there were several limitations of these trials. Network meta-analysis (NMA) is a recent tool for evidence-based medicine that draws strength from direct and indirect evidence generated from randomized control trials.
Nidhi Bhatnagar, P.V.M. Lakshmi, Kathiresan Jeyashree   +2 more
openaire   +3 more sources

Summary results of meta-analysis and indirect treatment comparison.

, 2016
Summary results of meta-analysis and indirect treatment comparison.
Hengjin Dong (398458), Suodi Zhai (3328581), Shuyan Gu (736892), Xuemei Zhen (3328584), Yiming Mu (288855), Yuhang Zeng (3328578)   +5 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Methods Used for Indirect Comparisons of Systemic Treatments for Psoriasis. A Systematic Review

Skin Health and Disease, 2022
Abstract Background Indirect comparisons (including network meta-analyses [NMAs]) allow us to compare benefits and risks of multiple interventions for the same clinical condition when head-to-head comparisons are not feasible. Objective
Alexander Nast, Corinna Dressler, Christopher Schuster, Daniel Saure, Matthias Augustin, Kristian Reich   +5 more
openaire   +3 more sources

Increasing transparency in indirect treatment comparisons: is selecting effect modifiers the missing part of the puzzle? A review of methodological approaches and critical considerations

Journal of Comparative Effectiveness Research, 2023
Failure to adjust for effect modifiers (EMs) in indirect treatment comparisons (ITCs) can produce biased and uncertain effect estimates. This is particularly important for health technology assessments (HTAs), where the availability of new treatments ...
Andreas Freitag, Laura Gurskyte, Grammati Sarri   +2 more
doaj   +1 more source