Results 31 to 40 of about 16,665 (202)

Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway

Frontiers in Microbiology, 2023
IntroductionAcute liver failure (ALF) is a clinical condition with many causes, fast progression, and a poor prognosis. Previous research has indicated that microbial factors have a role in ALF, but a clear picture has yet to emerge.MethodsTo investigate
Ziyuan Zhou, Baohong Wang, Xiaxia Pan, Jiawen Lv, Zhuoqi Lou, Yuqiu Han, Yuanyuan Yao, Jun Chen, Qiangqiang Wang, Lanjuan Li   +9 more
doaj   +1 more source

Indole-3-lactic acid protects the gut vascular barrier following intestinal ischemia injury through AhR/Nrf2/STAT3 mediated claudin 2 downregulation. [PDF]

Cell Commun Signal
Jia Y, He M, Wang F, Zhan Y, Deng Q, Shen J, Wang X, Ran Q, Huang W, Ling Y, Wen S.   +10 more
europepmc   +3 more sources

Production of Hydroxycarboxylic Acid Receptor 3 (HCA₃) Ligands by Bifidobacterium

Microorganisms, 2021
Hydroxycarboxylic acid receptor 3 (HCA3) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA3 ligands by Bifidobacterium spp.
Takuma Sakurai, Ayako Horigome, Toshitaka Odamaki, Takashi Shimizu, Jin-Zhong Xiao   +4 more
doaj   +1 more source

The intestine and the kidneys : a bad marriage can be hazardous [PDF]

, 2015
The concept that the intestine and chronic kidney disease influence each other, emerged only recently. The problem is multifaceted and bidirectional. On one hand, the composition of the intestinal microbiota impacts uraemic retention solute production ...
Glorieux, Griet, Vanholder, Raymond
core   +1 more source

UPLC-QTOF-MS/MS and GC-MS Characterization of Phytochemicals in Vegetable Juice Fermented Using Lactic Acid Bacteria from Kimchi and Their Antioxidant Potential

Antioxidants, 2021
This study aims to investigate fermentative metabolites in probiotic vegetable juice from four crop varieties (Brassica oleracea var. capitata, B. oleracea var. italica, Daucus carota L., and Beta vulgaris) and their antioxidant properties.
Moeun Lee, Jung Hee Song, Eun Ji Choi, Ye-Rang Yun, Ki Won Lee, Ji Yoon Chang   +5 more
doaj   +1 more source

Synbiotics of Lactobacillus suilingensis and inulin alleviates cognitive impairment via regulating gut microbiota indole-3-lactic acid metabolism in female AD mice. [PDF]

Alzheimers Dement
AbstractINTRODUCTIONRecent studies have found that gut microbial tryptophan metabolism is altered in Alzheimer's disease (AD) patients. However, the functional consequences of these changes and their therapeutic potential remain unclear.METHODSThe metagenomic data of 49 preclinical AD patients and 115 healthy controls were analyzed.
Yang C, Sun J, Li L, Zheng J, Wang C, Zhao Y, Yun D, Jia M, Wu Z, Liang H, Li W, Hu T, Guo R, Xiao L, Zou Y, Liu Z.   +15 more
europepmc   +2 more sources

Metabolic Modulation Predicts Heart Failure Tests Performance [PDF]

, 2019
The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple ...
Abbate, Antonio, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Contaifer, Daniel, Jr., Kumar, Naren G., Morriss, Joshua M., Ranasinghe, Asanga D., Trankle, Cory, Van Tassell, Benjamin W., Wijesinghe, Dayanjan S., Wohlford, George   +11 more
core   +3 more sources

Pharmacokinetic Properties of the Novel Synthetic Cannabinoid 5F-APINAC and Its Influence on Metabolites Associated with Neurotransmission in Rabbit Plasma

Pharmaceuticals, 2021
The strong psychoactive effects of synthetic cannabinoids raise the need for the deeper studying of their neurometabolic effects. The pharmacokinetic properties of 5F-APINAC and its influence on metabolomics profiles associated with neurotransmission ...
Ksenia M. Shestakova, Natalia V. Mesonzhnik, Pavel A. Markin, Natalia E. Moskaleva, Andrey A. Nedorubov, Alex Brito, Elizaveta G. Appolonova, Roman M. Kuznetsov, Natalia L. Bochkareva, Alexey Kukharenko, Alexey V. Lyundup, Franco Tagliaro, Svetlana A. Appolonova   +12 more
doaj   +1 more source

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]

, 2013
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB, Boyle, SH, Churchill, E, Delnomdedieu, M, Fiehn, O, Kaddurah-Daouk, R, Krishnan, RR, Pickering, E, Rush, AJ, Wang, Z, Wikoff, WR, Zhu, H   +11 more
core   +2 more sources

The role of bacterial metabolites derived from aromatic amino acids in non-alcoholic fatty liver disease

Alʹmanah Kliničeskoj Mediciny, 2020
The review deals with the role of aromatic amino acids and their microbial metabolites in the development and progression of non-alcoholic fatty liver disease (NAFLD).
E. S. Shcherbakova, T. S. Sall, S. I. Sitkin, T. Ya. Vakhitov, E. V. Demyanova   +4 more
doaj   +1 more source