Results 31 to 40 of about 17,012 (208)

Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis [PDF]

European Journal of Medical Research
Background Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize
Xiao Cao, Li Wang, Li Ning, Yang Hu, Nian Fu   +4 more
doaj   +2 more sources

Diabetes-associated modifications in gut microbiota and tryptophan metabolism: implications for macrophage polarization and wound repair in mice [PDF]

BMC Microbiology
Background Diabetic wound (DW) is a severe complication of diabetes with poor healing, linked to gut microbiota dysbiosis, metabolic imbalance, and macrophage polarization disorder. This study aimed to systematically explore the role of the gut-skin axis
Yiming Ni, Jiawei Feng, Wei Zhang, Min Tang, Shiyu Wang, Rong Shi, Mingmei Zhou, Cheng Zhao   +7 more
doaj   +2 more sources

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
doaj   +1 more source

Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from C. diff Infection

iScience, 2020
Summary: Clostridioides difficile (C. diff) is the leading cause of antibiotic-associated colitis. Here, we report that lemon exosome-like nanoparticles (LELNs) manipulated probiotics to inhibit C. diff infection (CDI).
Chao Lei, Jingyao Mu, Yun Teng, Liqing He, Fangyi Xu, Xiangcheng Zhang, Kumaran Sundaram, Anil Kumar, Mukesh K. Sriwastva, Matthew B. Lawrenz, Lifeng Zhang, Jun Yan, Wenke Feng, Craig J. McClain, Xiang Zhang, Huang-Ge Zhang   +15 more
doaj   +1 more source

2'-fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice. [PDF]

, 2020
Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety signaling, which may be due in part to gut microbial dysbiosis. Manipulations of the gut microbiota and its metabolites are attractive targets for obesity treatment ...
Barile, Daniela, Goodson, Michael, Kalanetra, Karen, Lee, Sunhye, Raybould, Helen, Vang, Wendie   +5 more
core   +1 more source

Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand.

PLoS ONE, 2020
Indole-3-acetic acid (IAA) is an imperative phytohormone for plant growth and development. Ectomycorrhizal fungi (ECM) are able to produce IAA. However, only a few studies on IAA biosynthesis pathways in ECM fungi have been reported.
Jaturong Kumla, Nakarin Suwannarach, Kenji Matsui, Saisamorn Lumyong   +3 more
doaj   +1 more source

Determination of Tryptophan Metabolites in Serum and Cerebrospinal Fluid Samples Using Microextraction by Packed Sorbent, Silylation and GC–MS Detection

Molecules, 2020
Indole-containing acids—tryptophan metabolites—found in serum and cerebrospinal fluid (CSF) samples of patients with diseases of the central nervous system (CNS) were determined with the use of microextraction by packed sorbent (MEPS) followed by ...
Alisa Pautova, Zoya Khesina, Maria Getsina, Pavel Sobolev, Alexander Revelsky, Natalia Beloborodova   +5 more
doaj   +1 more source

Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study

Microorganisms, 2021
Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance of Akkermansia is positively correlated with tryptophan metabolism.
Jia Yin, Yujie Song, Yaozhong Hu, Yuanyifei Wang, Bowei Zhang, Jin Wang, Xuemeng Ji, Shuo Wang   +7 more
doaj   +1 more source

Aryl hydrocarbon receptor activation during in vitro and in vivo digestion of raw and cooked broccoli (brassica oleracea var. Italica) [PDF]

, 2020
Broccoli is rich in glucosinolates, which can be converted upon chewing and processing into Aryl hydrocarbon Receptor (AhR) ligands. Activation of AhR plays an important role in overall gut homeostasis but the role of broccoli processing on the ...
Capuano, Edoardo, Fogliano, Vincenzo, Gill, Chris I. R., Huang, Zhan, Koper, Jonna E. B., Kortekaas, Maaike, Loonen, Linda M. P., McDougall, Gordon, Pereira-Caro, Gema, Pourshahidi, L. Kirsty, Rowland, Ian, Wells, Jerry M.   +11 more
core   +4 more sources

Characterization of indole-3-pyruvic acid pathway-mediated biosynthesis of auxin in Neurospora crassa. [PDF]

PLoS ONE, 2018
Plants, bacteria and some fungi are known to produce indole-3-acetic acid (IAA) by employing various pathways. Among these pathways, the indole-3-pyruvic acid (IPA) pathway is the best studied in green plants and plant-associated beneficial microbes ...
Puspendu Sardar, Frank Kempken
doaj   +1 more source