Results 11 to 20 of about 9,369 (148)

Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan [PDF]

Gut Microbes
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction after ...
Cheng Chung Yong, Takuma Sakurai, Hiroki Kaneko, Ayako Horigome, Eri Mitsuyama, Aruto Nakajima, Toshihiko Katoh, Mikiyasu Sakanaka, Takaaki Abe, Jin-Zhong Xiao, Miyuki Tanaka, Toshitaka Odamaki, Takane Katayama   +12 more
doaj   +4 more sources

Integrative network pharmacology and machine learning identify potential targets of indole-3-lactic acid in colorectal cancer [PDF]

PLoS ONE
The treatment of colorectal cancer (CRC) remains challenging due to chemotherapy resistance and genetic heterogeneity. Indole-3-lactic acid (ILA), a tryptophan metabolite derived from gut microbiota, exhibits promising anti-inflammatory and anticancer properties; however, its specific molecular targets and regulatory mechanisms in CRC remain poorly ...
Jie Li, Jian Zhang, Jun Ke, Zhijian Ren, Cuncheng Feng   +4 more
doaj   +4 more sources

Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation [PDF]

Journal of Neuroinflammation
Background Depression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and ...
Yuhao Wang, Jun Gong, Kexin Geng, Xia Chen, Mengzhen Jia, Cong Yang, Silu Zhang, Jie Pan, Rongrong Wu, Zhigang Liu, Tian Yuan   +10 more
doaj   +5 more sources

Bacterial indole-3-lactic acid affects epithelium–macrophage crosstalk to regulate intestinal homeostasis [PDF]

Proceedings of the National Academy of Sciences, 2023
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia coli strain ( Ec-
Kaiyuan Yu, Qianqian Li, Xuan Sun, Xianping Peng, Qiang Tang, Hongyu Chu, Lu Zhou, Bangmao Wang, Zhemin Zhou, Xueqin Deng, Jianming Yang, Junqiang Lv, Ran Liu, Chunhui Miao, Wei Zhao, Zhi Yao, Quan Wang   +16 more
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Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells [PDF]

BMC Microbiology, 2020
Abstract Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesized that metabolites from B.
A Ehrlich, Alline R. Pacheco, Bethany M. Henrick, Diana H. Taft, Gege Xu, Md. Nazmul Huda, Darya O. Mishchuk, Michael L. Goodson, Carolyn M. Slupsky, Daniela Barile, Carlito B. Lebrilla, Charles B. Stephensen, David A. Mills, Helen E. Raybould   +13 more
openaire   +5 more sources

Metabolites of Kimchi Lactic Acid Bacteria, Indole-3-Lactic Acid, Phenyllactic Acid, and Leucic Acid, Inhibit Obesity-Related Inflammation in Human Mesenchymal Stem Cells [PDF]

Journal of Microbiology and Biotechnology, 2023
Given the diversity of vegetables utilized in food fermentation and various lactic acid bacteria (LAB) populations in these materials, comprehensive studies on LAB from vegetable foods, including kimchi, are imperative. Therefore, this study aimed to investigate the obesity-related inflammation response of three metabolites-phenyllactic acid (PLA ...
Lee, Moeun, Kim, Daun, Chang, Ji Yoon
openaire   +3 more sources

Lactobacillus-derived indole-3-lactic acid ameliorates colitis in cesarean-born offspring via activation of aryl hydrocarbon receptor [PDF]

iScience, 2023
Cesarean section (CS) delivery is known to disrupt the transmission of maternal microbiota to offspring, leading to an increased risk of inflammatory bowel disease (IBD). However, the underlying mechanisms remain poorly characterized. Here, we demonstrate that CS birth renders mice susceptible to dextran sulfate sodium (DSS)-induced colitis and impairs
Xia, Yanan, Liu, Chang, Li, Ruijia, Zheng, Mengqi, Feng, Bingcheng, Gao, Jiahui, Long, Xin, Li, Lixiang, Li, Shiyang, Zuo, Xiuli, Li, Yanqing   +10 more
openaire   +3 more sources

Neonatal gut Bifidobacterium associates with indole-3-lactic acid levels in blood and risk of ADHD at age 10 [PDF]

Molecular Psychiatry
Abstract The gut microbiome has been associated with brain health. The neuromodulatory effects of microbial-derived metabolites is supported by experimental evidence, and alterations of gut microbiota have been associated with the pathophysiology of certain neuropsychiatric disorders. Research on
Michael Widdowson, Shiraz Shah, Jonathan Thorsen, Casper Sahl Poulsen, Julie B. Rosenberg, Parisa Mohammadzadeh, Jens Richardt Moellegaard Jepsen, Rebecca Vinding, Christina Egeø Poulsen, Cristina Leal Rodriguez, Casper-Emil T. Pedersen, Tingting Wang, Trine Zachariasen, Filip Ottosson, Thomas Mears Werge, Madeleine Ernst, Søren Johannes Sørensen, Bo Chawes, Klaus Bønnelykke, Urvish Trivedi, Bjørn H. Ebdrup, Jakob Stokholm   +21 more
openaire   +3 more sources

Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria

Microorganisms
Lactic acid Bacteria (LAB) convert tryptophan to indole derivatives and induce protective IL-22 production in vivo. However, differences in metabolizing capabilities among LAB species have not been widely investigated.
Bingyang Ma, Yan Zhao, Liping Liu, Jianguo Xu, Qingping Hu, Saisai Feng, Liangliang Zhang   +6 more
doaj   +3 more sources

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine [PDF]

Pediatric Research, 2020
Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best protection.
Meng D., Sommella E., Salviati E., Campiglia P., Ganguli K., Djebali K., Zhu W., Walker W. A.   +7 more
openaire   +4 more sources