Results 11 to 20 of about 545,403 (187)

Integrative network pharmacology and machine learning identify potential targets of indole-3-lactic acid in colorectal cancer [PDF]

PLoS ONE
The treatment of colorectal cancer (CRC) remains challenging due to chemotherapy resistance and genetic heterogeneity. Indole-3-lactic acid (ILA), a tryptophan metabolite derived from gut microbiota, exhibits promising anti-inflammatory and anticancer ...
Jie Li, Jian Zhang, Jun Ke, Zhijian Ren, Cuncheng Feng   +4 more
doaj   +5 more sources

Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria

Microorganisms
Lactic acid Bacteria (LAB) convert tryptophan to indole derivatives and induce protective IL-22 production in vivo. However, differences in metabolizing capabilities among LAB species have not been widely investigated.
Bingyang Ma, Yan Zhao, Liping Liu, Jianguo Xu, Qingping Hu, Saisai Feng, Liangliang Zhang   +6 more
doaj   +4 more sources

Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation [PDF]

Journal of Neuroinflammation
Background Depression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and ...
Yuhao Wang, Jun Gong, Kexin Geng, Xia Chen, Mengzhen Jia, Cong Yang, Silu Zhang, Jie Pan, Rongrong Wu, Zhigang Liu, Tian Yuan   +10 more
doaj   +5 more sources

Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models [PDF]

International Journal of Molecular Sciences, 2022
Indole-3-lactic acid (I3LA) is a well-known metabolite involved in tryptophan metabolism. Indole derivatives are involved in the differentiation of immune cells and the synthesis of cytokines via the aryl hydrocarbon receptors for modulating immunity, and the indole derivatives may be involved in allergic responses.
Gun Yong Sung, Sung Gun Yong
exaly   +4 more sources

Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand.

PLoS ONE, 2020
Indole-3-acetic acid (IAA) is an imperative phytohormone for plant growth and development. Ectomycorrhizal fungi (ECM) are able to produce IAA. However, only a few studies on IAA biosynthesis pathways in ECM fungi have been reported.
Jaturong Kumla, Nakarin Suwannarach, Kenji Matsui, Saisamorn Lumyong   +3 more
doaj   +2 more sources

Tryptophan metabolites and stroke risk after acute myocardial infarction in patients with and without metabolic syndrome: insights from a MACCE-based cohort [PDF]

Cardiovascular Diabetology
Background Metabolic syndrome (MetS) obviously increases the risk of major adverse cardiac and cerebrovascular events (MACCE) in patients with acute myocardial infarction (AMI).
Lili Xiu, Yan Liu, Pengyan Wu, Meng Wang, Haoning Cui, Jiawei Zhao, Lina Cui, Huai Yu, Guo Wei, Chao Fang, Jiannan Dai, Shaohong Fang, Bo Yu   +12 more
doaj   +2 more sources

Serum microbiome-related metabolites—including short-chain fatty acids and indole derivatives—predict outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a two-timepoint LC–MS study [PDF]

Frontiers in Neurology
BackgroundDelayed cerebral ischemia (DCI) remains a major determinant of poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). Growing evidence suggests that gut microbiota–derived metabolites, including short-chain fatty acids (SCFAs) and ...
Blanka Nagybanyai-Nagy, Roland Tengölics, Csilla Sajben, Dominika Olasz, Attila Schwarcz, Tihamer Molnar, Peter Csecsei   +6 more
doaj   +2 more sources

Gut microbiota–derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health [PDF]

Frontiers in Veterinary Science
Tryptophan, an essential amino acid, has nutritional value. Beyond that, it is an important signaling molecule that connects the gut microbiota with host physiology.
Yang Wen
doaj   +2 more sources

Effects of Saccharomyces cerevisiae on the regulation of skatole, microorganisms, and tryptophan metabolites in vitro fermentation of pig [PDF]

Microbiology Spectrum
Skatole (3-methylindole), one of the most malodorous compounds from swine manure, poses serious risks to animal, human, and environmental health. Therefore, it has become a serious concern in livestock farming.
Xiaoli Gao, Shengwei Zhang, Shanshan Ge, Qiaoli Yang, Shuangbao Gun   +4 more
doaj   +2 more sources

Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis. [PDF]

Proc Natl Acad Sci U S A, 2023
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia coli strain ( Ec- TMU) isolated from the feces of ...
Yu K, Li Q, Sun X, Peng X, Tang Q, Chu H, Zhou L, Wang B, Zhou Z, Deng X, Yang J, Lv J, Liu R, Miao C, Zhao W, Yao Z, Wang Q.   +16 more
europepmc   +3 more sources