Results 21 to 30 of about 545,403 (187)

Safety Evaluation of Weissella paramesenteroides MW-142 Isolated From Traditional Fermented Mulberry Wine. [PDF]

Microbiologyopen
Integrated safety evaluation of Weissella paramesenteroides MW‐142 from traditional fermented mulberry wine demonstrates no acute oral toxicity, non‐hemolytic activity, absence of harmful metabolites, and only intrinsic, non‐mobile antibiotic resistance genes, supporting its potential as a safe candidate for probiotic or biopreservative applications ...
Huang J, Huang YY, Liu DM, Yao QB, Tang J, Zeng SP, Liu LJ.   +6 more
europepmc   +2 more sources

The Effect of Indole-3-Lactic Acid from Lactiplantibacillus plantarum ZJ316 on Human Intestinal Microbiota In Vitro. [PDF]

Foods, 2022
Microbiota-derived tryptophan metabolites are essential signals for maintaining gut homeostasis, yet the potential contribution to modulating gut microbiota has been rarely investigated. In this study, Lactiplantibacillus plantarum ZJ316 (CCTCC No. M 208077) with a high production (43.14 μg/mL) of indole-3-lactic acid (ILA) was screened. ILA with 99.00%
Zhou Q, Xie Z, Wu D, Liu L, Shi Y, Li P, Gu Q.   +6 more
europepmc   +4 more sources

Lactobacillus-derived indole-3-lactic acid ameliorates colitis in cesarean-born offspring via activation of aryl hydrocarbon receptor. [PDF]

iScience, 2023
Cesarean section (CS) delivery is known to disrupt the transmission of maternal microbiota to offspring, leading to an increased risk of inflammatory bowel disease (IBD). However, the underlying mechanisms remain poorly characterized. Here, we demonstrate that CS birth renders mice susceptible to dextran sulfate sodium (DSS)-induced colitis and impairs
Xia Y, Liu C, Li R, Zheng M, Feng B, Gao J, Long X, Li L, Li S, Zuo X, Li Y.   +10 more
europepmc   +3 more sources

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. [PDF]

BMC Microbiol, 2020
Abstract Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesized that metabolites from B.
Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, Lebrilla CB, Stephensen CB, Mills DA, Raybould HE.   +13 more
europepmc   +6 more sources

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine. [PDF]

Pediatr Res, 2020
Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best protection.
Meng D, Sommella E, Salviati E, Campiglia P, Ganguli K, Djebali K, Zhu W, Walker WA.   +7 more
europepmc   +4 more sources

Neonatal gut Bifidobacterium associates with indole-3-lactic acid levels in blood and risk of ADHD at age 10. [PDF]

Mol Psychiatry
Abstract The gut microbiome has been associated with brain health. The neuromodulatory effects of microbial-derived metabolites is supported by experimental evidence, and alterations of gut microbiota have been associated with the pathophysiology of certain neuropsychiatric disorders. Research on
Widdowson M, Shah S, Thorsen J, Poulsen CS, Rosenberg JB, Mohammadzadeh P, Jepsen JRM, Vinding R, Poulsen CE, Rodriguez CL, Pedersen CT, Wang T, Zachariasen T, Ottosson F, Werge TM, Ernst M, Sørensen SJ, Chawes B, Bønnelykke K, Trivedi U, Ebdrup BH, Stokholm J.   +21 more
europepmc   +2 more sources

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2. [PDF]

J Transl Med, 2023
Abstract Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus (L. murinus)-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury yet to be investigated.
Zhang FL, Chen XW, Wang YF, Hu Z, Zhang WJ, Zhou BW, Ci PF, Liu KX.   +7 more
europepmc   +4 more sources

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
doaj   +1 more source

Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from C. diff Infection

iScience, 2020
Summary: Clostridioides difficile (C. diff) is the leading cause of antibiotic-associated colitis. Here, we report that lemon exosome-like nanoparticles (LELNs) manipulated probiotics to inhibit C. diff infection (CDI).
Chao Lei, Jingyao Mu, Yun Teng, Liqing He, Fangyi Xu, Xiangcheng Zhang, Kumaran Sundaram, Anil Kumar, Mukesh K. Sriwastva, Matthew B. Lawrenz, Lifeng Zhang, Jun Yan, Wenke Feng, Craig J. McClain, Xiang Zhang, Huang-Ge Zhang   +15 more
doaj   +1 more source

Determination of Tryptophan Metabolites in Serum and Cerebrospinal Fluid Samples Using Microextraction by Packed Sorbent, Silylation and GC–MS Detection

Molecules, 2020
Indole-containing acids—tryptophan metabolites—found in serum and cerebrospinal fluid (CSF) samples of patients with diseases of the central nervous system (CNS) were determined with the use of microextraction by packed sorbent (MEPS) followed by ...
Alisa Pautova, Zoya Khesina, Maria Getsina, Pavel Sobolev, Alexander Revelsky, Natalia Beloborodova   +5 more
doaj   +1 more source