Results 21 to 30 of about 9,369 (148)

Microbiome-Derived Indole-3-Lactic Acid Attenuates Cutibacterium Acnes-Induced Inflammation via the Aryl Hydrocarbon Receptor Pathway [PDF]

International Journal of Molecular Sciences
Acne vulgaris is a chronic inflammatory dermatosis where conventional therapies often face limitations in efficacy and safety, necessitating the development of microbiome-targeted interventions. This study investigated the immunomodulatory potential of microbiome-derived tryptophan metabolites as a novel therapeutic strategy for Cutibacterium acnes (C.
Sang Gyu Lee, Nam Hao Chau, Seoyoon Ham, Yujin Baek, Ngoc Ha Nguyen, Seon Hwa Kim, Young In Lee   +6 more
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Indole‐3‐Lactic Acid Inhibits Doxorubicin‐Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway [PDF]

Journal of Cellular and Molecular Medicine
ABSTRACTThe clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and myocardial ferroptosis. This study aimed to investigate the role of the gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), in mitigating DOX‐
Jiangfang Lian, Hui Lin, Zuoquan Zhong, Yongfei Song, Xian Shao, Jiedong Zhou, Lili Xu, Zhenzhu Sun, Yongyi Yang, Jufang Chi, Ping Wang, Liping Meng   +11 more
openaire   +3 more sources

Tryptophan metabolites and stroke risk after acute myocardial infarction in patients with and without metabolic syndrome: insights from a MACCE-based cohort [PDF]

Cardiovascular Diabetology
Background Metabolic syndrome (MetS) obviously increases the risk of major adverse cardiac and cerebrovascular events (MACCE) in patients with acute myocardial infarction (AMI).
Lili Xiu, Yan Liu, Pengyan Wu, Meng Wang, Haoning Cui, Jiawei Zhao, Lina Cui, Huai Yu, Guo Wei, Chao Fang, Jiannan Dai, Shaohong Fang, Bo Yu   +12 more
doaj   +2 more sources

Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis [PDF]

Microbiome
Intake of dietary fiber is associated with a reduced risk of inflammatory bowel disease. β-Glucan (BG), a bioactive dietary fiber, has potential health-promoting effects on intestinal functions; however, the underlying mechanism remains unclear.
Shanshan Zhang, Qixing Nie, Yonggan Sun, Sheng Zuo, Chunhua Chen, Song Li, Jingrui Yang, Jielun Hu, Xingtao Zhou, Yongkang Yu, Ping Huang, Lu Lian, Mingyong Xie, Shaoping Nie   +13 more
openaire   +4 more sources

Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A [PDF]

Psoriasis: Targets and Therapy
Zhen Meng,1,* Jieru Ren,2,* Yuhsien Lai,3 Siyao Lu,2 Huiyan Wu,2 Yanyun Jiang,2 Zhan Zhang,4 Guozhen Tan,2 Zhenrui Shi2 1Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of China ...
Meng Z, Ren J, Lai Y, Lu S, Wu H, Jiang Y, Zhang Z, Tan G, Shi Z   +8 more
doaj   +2 more sources

Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages [PDF]

Theranostics
Aim: To elucidate dynamics and functions in colonic macrophage subsets, and their regulation by Bifidobacterium breve (B. breve) and its associated metabolites in the initiation of colitis-associated colorectal cancer (CAC). Methods: Azoxymethane (AOM) and dextran sodium sulfate (DSS) were used to create a CAC model.
Li, Yuke, Li, Qingxiang, Yuan, Ruoshui, Wang, Yifei, Guo, Chuanbin, Wang, Lin   +5 more
openaire   +3 more sources

Serum microbiome-related metabolites—including short-chain fatty acids and indole derivatives—predict outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a two-timepoint LC–MS study [PDF]

Frontiers in Neurology
BackgroundDelayed cerebral ischemia (DCI) remains a major determinant of poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). Growing evidence suggests that gut microbiota–derived metabolites, including short-chain fatty acids (SCFAs) and ...
Blanka Nagybanyai-Nagy, Roland Tengölics, Csilla Sajben, Dominika Olasz, Attila Schwarcz, Tihamer Molnar, Peter Csecsei   +6 more
doaj   +2 more sources

Effects of Saccharomyces cerevisiae on the regulation of skatole, microorganisms, and tryptophan metabolites in vitro fermentation of pig [PDF]

Microbiology Spectrum
Skatole (3-methylindole), one of the most malodorous compounds from swine manure, poses serious risks to animal, human, and environmental health. Therefore, it has become a serious concern in livestock farming.
Xiaoli Gao, Shengwei Zhang, Shanshan Ge, Qiaoli Yang, Shuangbao Gun   +4 more
doaj   +2 more sources

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
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Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from C. diff Infection

iScience, 2020
Summary: Clostridioides difficile (C. diff) is the leading cause of antibiotic-associated colitis. Here, we report that lemon exosome-like nanoparticles (LELNs) manipulated probiotics to inhibit C. diff infection (CDI).
Chao Lei, Jingyao Mu, Yun Teng, Liqing He, Fangyi Xu, Xiangcheng Zhang, Kumaran Sundaram, Anil Kumar, Mukesh K. Sriwastva, Matthew B. Lawrenz, Lifeng Zhang, Jun Yan, Wenke Feng, Craig J. McClain, Xiang Zhang, Huang-Ge Zhang   +15 more
doaj   +1 more source