Results 1 to 10 of about 248 (125)
Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
Gut MicrobesResearch indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear.
Shizhen Zhou +11 more
doaj +5 more sources
Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells [PDF]
Microorganisms, 2020 Gut microbiota-derived tryptophan metabolites such as indole derivatives are an integral part of host metabolome that could mediate gut−brain communication and contribute to host homeostasis.
Chyn Boon Wong +3 more
doaj +5 more sources
Frontiers in Plant ScienceBacillus species are recognized as plant growth-promoting bacteria (PGPB), yet the mechanisms behind their crop growth promotion remain elusive. This study is designed to explore the plant growth-promoting (PGP) effects of Bacillus megaterium GXU087 on ...
Jingsi Qiu +6 more
doaj +5 more sources
Cell Reports MedicineSummary: The escalating global prevalence of depression demands effective therapeutic strategies, with psychobiotics emerging as a promising solution. However, the molecular mechanisms governing the neurobehavioral impact of psychobiotics remain elusive.
Xin Qian +8 more
doaj +5 more sources
Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants [PDF]
Microorganisms, 2019 Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai +2 more
doaj +3 more sources
Foods, 2022 Microbiota-derived tryptophan metabolites are essential signals for maintaining gut homeostasis, yet the potential contribution to modulating gut microbiota has been rarely investigated. In this study, Lactiplantibacillus plantarum ZJ316 (CCTCC No. M 208077) with a high production (43.14 μg/mL) of indole-3-lactic acid (ILA) was screened. ILA with 99.00%
Qing Gu, Qingqing Zhou, Yongqing Shi
exaly +4 more sources
Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid
Applied Microbiology and BiotechnologyIntestinal bacteria can convert indole to a range of compounds; however, the precise enzymatic processes facilitating this conversion have not been fully elucidated.
Hiroaki Konishi +5 more
doaj +4 more sources
The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis [PDF]
Scientific Reports, 2021 An excessive intestinal inflammatory response may have a role in the pathogenesis of necrotizing enterocolitis (NEC) in very preterm infants. Indole-3-lactic acid (ILA) of breastmilk tryptophan was identified as the anti-inflammatory metabolite involved ...
Wuyang Huang +3 more
doaj +3 more sources
Microbial Cell FactoriesPrevious studies showed that the female genital tract microbiome plays a crucial role in regulating the host’s immune defense mechanisms. Our previous research has shown that Lactobacillus gasseri LGV03 (L.
Zikang Zhang +6 more
doaj +3 more sources
Improvement of Insulin Resistance by Lactobacillus johnsonii-Derived Indole-3-Lactic Acid
MicroorganismsInsulin resistance (IR), a primary pathological driver of dysregulated glucose and lipid metabolism, is closely associated with elevated oxidative stress. Gut microbiota contributes to IR via bioactive metabolites.
Jie-Lin Zhan +11 more
doaj +2 more sources