Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants [PDF]
Microorganisms, 2019 Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai +2 more
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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming [PDF]
Gut MicrobesResearch indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear.
Shizhen Zhou +11 more
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Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation [PDF]
Cell Reports MedicineSummary: The escalating global prevalence of depression demands effective therapeutic strategies, with psychobiotics emerging as a promising solution. However, the molecular mechanisms governing the neurobehavioral impact of psychobiotics remain elusive.
Xin Qian +8 more
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Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan [PDF]
Gut MicrobesIndole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction after ...
Cheng Chung Yong +12 more
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Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells [PDF]
Microorganisms, 2020 Gut microbiota-derived tryptophan metabolites such as indole derivatives are an integral part of host metabolome that could mediate gut−brain communication and contribute to host homeostasis.
Chyn Boon Wong +3 more
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Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid [PDF]
Applied Microbiology and BiotechnologyIntestinal bacteria can convert indole to a range of compounds; however, the precise enzymatic processes facilitating this conversion have not been fully elucidated.
Hiroaki Konishi +5 more
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Bacillus megaterium GXU087 secretes indole - 3 - lactic acid to promote soybean growth and nodulation [PDF]
Frontiers in Plant ScienceBacillus species are recognized as plant growth-promoting bacteria (PGPB), yet the mechanisms behind their crop growth promotion remain elusive. This study is designed to explore the plant growth-promoting (PGP) effects of Bacillus megaterium GXU087 on ...
Jingsi Qiu +6 more
doaj +4 more sources
Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor [PDF]
Microbial Cell FactoriesPrevious studies showed that the female genital tract microbiome plays a crucial role in regulating the host’s immune defense mechanisms. Our previous research has shown that Lactobacillus gasseri LGV03 (L.
Zikang Zhang +6 more
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The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis [PDF]
Scientific Reports, 2021 An excessive intestinal inflammatory response may have a role in the pathogenesis of necrotizing enterocolitis (NEC) in very preterm infants. Indole-3-lactic acid (ILA) of breastmilk tryptophan was identified as the anti-inflammatory metabolite involved ...
Wuyang Huang +3 more
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Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A [PDF]
Psoriasis: Targets and TherapyZhen Meng,1,* Jieru Ren,2,* Yuhsien Lai,3 Siyao Lu,2 Huiyan Wu,2 Yanyun Jiang,2 Zhan Zhang,4 Guozhen Tan,2 Zhenrui Shi2 1Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of China ...
Meng Z +8 more
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