Results 51 to 60 of about 16,665 (202)

Bioactive compounds derived from the yeast metabolism of aromatic amino acids during alcoholic fermentation [PDF]

, 2014
Metabolites resulting from nitrogen metabolism in yeast are currently found in some fermented beverages such as wine and beer. Their study has recently attracted the attention of researchers.
Beltrán, Gemma, Cerezo López, Ana Belén, García Parrilla, María del Carmen, Guillamón, José Manuel, Mas, Albert, Torija Martínez, María Jesús, Troncoso González, Ana María   +6 more
core   +4 more sources

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Feed interventions and skatole deposition [PDF]

, 2012
Skatole produced in the large intestine of the pig and the testicular steroid androstenone are the main substances contributing to boar tainted meat from entire male pigs.
Jensen, Rikke Lassen
core  

Stable isotope profiles reveal active production of VOCs from human-associated microbes. [PDF]

, 2017
Volatile organic compounds (VOCs) measured from exhaled breath have great promise for the diagnosis of bacterial infections. However, determining human or microbial origin of VOCs detected in breath remains a great challenge.
Barletta, Barbara, Blake, Donald R, Meinardi, Simone, Phan, Joann, Whiteson, Katrine   +4 more
core   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Review: Pharmacological effects of Capparis spinosa L. [PDF]

, 2016
Medicinal plants have been known as one of the most important therapeutic agents since ancient times. During the last two decades, much attention has been paid to the health-promoting effects of edible medicinal plants, because of multiple beneficial ...
Abraham, Afsharypuor, Ageel, Aggarwal, Aghel, Ahmed, Ahvazi, Aichour, Al-Qura'n, Al-Soqeer, Aliyazicioglu, Allaith, Arena, Argentieri, Asl, Attrey, Banel, Barbera, Barbera, Benzidane, Bhattacharya, Biswas, Bonina, Bouriche, Caboni, Cao, Dillard, Dragicevic, Eddouks, Erdem, Erdogan, Esiyok, Feng, Fici, Fici, Fici, Fici, Francesca, Fu, Fu, Gadgoli, Germano, Giuffrida, Goel, Gull, Gurney, Habtemariam, Habtemariam, Habtemariam, Habtemariam, Higton, Holst, Hu, Huseini, Ihme, Inocencio, Inocencio, Jacobs, Jiang, Kara, Kim, Kulisic-Bilusic, Kulisic-Bilusic, Lam, Lansky, Li, Lin, Macchia, Maire, Matthäus, Miraldi, Mishra, Mishra, Moghaddasi, Mohammad, Mosaddegh, Musallam, Nabavi, Nabavi, Nabavi, Nabavi, Nabavi, Ngameni, Polat, Pérez Pulido, Raskin, Rivera, Rivera, Rodrigo, Romeo, Russo, Saraf, Schraudolf, Schulz, Sen, Sharaf, Sher, Siracusa, Tesi, Tesoriere, Tlili, Tlili, Tlili, Tranchimand, Turgut, Wink, Yang, Yaniv, Yu, Zhang, Zhou, Zhou, Zohary, Çaliş, Çalış   +114 more
core   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Differences in the Profile of Aromatic Metabolites in the Corresponding Blood Serum and Cerebrospinal Fluid Samples of Patients with Secondary Bacterial Meningitis

Metabolites
Background: Secondary (nosocomial) bacterial meningitis remains a serious problem in patients with severe brain damage. The aim of this study was to assess the differences in the aromatic metabolites of tryptophan, phenylalanine, and tyrosine, in serum ...
Alisa K. Pautova, Peter A. Meinarovich, Vladislav E. Zakharchenko, Pavel D. Sobolev, Natalia A. Burnakova, Natalia V. Beloborodova   +5 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Bacterial Production of Indole Related Compounds Reveals Their Role in Association Between Duckweeds and Endophytes

Frontiers in Chemistry, 2018
Duckweed farming can be a sustainable practice for biofuel production, animal feed supplement, and wastewater treatment, although large scale production remains a challenge.
Sarah Gilbert, Jenny Xu, Kenneth Acosta, Alexander Poulev, Sarah Lebeis, Eric Lam   +5 more
doaj   +1 more source