Results 61 to 70 of about 16,665 (202)

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria

Microorganisms
Lactic acid Bacteria (LAB) convert tryptophan to indole derivatives and induce protective IL-22 production in vivo. However, differences in metabolizing capabilities among LAB species have not been widely investigated.
Bingyang Ma, Yan Zhao, Liping Liu, Jianguo Xu, Qingping Hu, Saisai Feng, Liangliang Zhang   +6 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism

Frontiers in Immunology, 2022
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disorder in the gastrointestinal tract. Here, we examined the pharmacological effects of ginsenoside Rg1, a natural compound with low bioavailability, on the acute experimental colitis mice ...
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Yuzhu Tan, Wuwen Feng, Wuwen Feng, Cheng Peng, Cheng Peng   +9 more
doaj   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Longitudinal Modulation of the Gut Microbiome and Growth Performance by Phytochemicals as Antibiotic Alternatives in Swine Production

Animal Research and One Health, EarlyView.
We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu, Samantha Howe, Yang Tian, Alisun N. Watson, Jason E. Farrar, Christopher E. Randolph, Jaime Andrés Ángel Isaza, Álvaro José Uribe, Yan Huang, Michael Looper, Jiangchao Zhao, Tsungcheng Tsai   +11 more
wiley   +1 more source

Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin

Microbiology Spectrum
Tryptophan (TRP) metabolites have been identified as potent biomarkers for complications of type 2 diabetes mellitus (T2DM). However, it remains unclear whether the therapeutic effect of metformin in T2DM is related to the modulation of TRP metabolic ...
Yvhao Xie, Xinxin Li, Qingshi Meng, Jinjun Li, Xin Wang, Liying Zhu, Weiwei Wang, Xiaoqiong Li   +7 more
doaj   +1 more source

Comprehensive analysis of metabolites produced by co-cultivation of Bifidobacterium breve MCC1274 with human iPS-derived intestinal epithelial cells

Frontiers in Microbiology, 2023
Examining how host cells affect metabolic behaviors of probiotics is pivotal to better understand the mechanisms underlying the probiotic efficacy in vivo.
Akira Sen, Tatsuki Nishimura, Shin Yoshimoto, Keisuke Yoshida, Aina Gotoh, Toshihiko Katoh, Yasuko Yoneda, Toyoyuki Hashimoto, Jin-Zhong Xiao, Takane Katayama, Toshitaka Odamaki   +10 more
doaj   +1 more source

Catabolism of Amino Acids in the Cells of Lactic Acid Bacteria [PDF]

, 2011
Bakterije mliječne kiseline su auksotrofni industrijski mikroorganizmi i uzgajaju se u hranjivim podlogama kompleksnog sastava. Između ostalih sastojaka, u hranjive podloge u kojima se uzgajaju ove bakterije potrebno je dodati i određene aminokiseline ...
Anamarija Perković, Anita Slavica, Antonija Trontel, Marina Pupovac, Nuša Jelovac   +4 more
core   +1 more source

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source