Results 81 to 90 of about 9,369 (148)

Lactobacillus plantarum-derived indole-3-lactic acid inhibits prostate cancer progression through ASF1B/ENO1 axis and remodels the tumor microenvironment to enhance anti-PD-1 therapy

Molecular Biomedicine
Prostate cancer (PCa) is one of the most common cancers in males, and its treatment remains challenging due to the tumor microenvironment (TME) with immunosuppressive properties and limited response to anti-PD-1 therapy.
Zhengshi Wang, Chengyou Jia, Yongqiang Liu, Youlutuziayi Rixiati, Wentao Zhang, Shiyu Mao, Haotian Chen, Libin Zou, Chen Ye, Bing Shen, Xudong Yao   +10 more
doaj   +1 more source

Nutrients, Phytochemicals, and Antioxidant Capacity of Red Raspberry Nectar Fermented with Lacticaseibacillus paracasei

Foods
Fresh raspberries are highly perishable, but lactic acid bacteria fermentation offers a favourable method for developing healthy products. This study investigated the effects of Lacticaseibacillus paracasei fermentation on the nutrients and ...
Feng Shi, Yin Qin, Shuyi Qiu, You Luo
doaj   +1 more source

Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding

Microbiome
Background The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology.
Gang Wang, Yuxin Fan, Guolong Zhang, Shuang Cai, Yonghang Ma, Lijie Yang, Yuming Wang, Haitao Yu, Shiyan Qiao, Xiangfang Zeng   +9 more
doaj   +1 more source

Microbiota-derived IPA mitigates post-stroke neuroinflammation by inhibiting TREM2-dependent pyroptosis

Journal of Neuroinflammation
Ischemic stroke remains the leading cause of long-term disability globally, underscoring the urgent need for novel therapeutic strategies. Here, we explore a microbiota-gut-brain axis that provides valuable insights for achieving this objective ...
Jun-Min Chen, Cong Zhang, Lu-Lu Yu, Jian-Xu Sun, Jiang-Hao Zhang, Lu Chen, Fei Zhu, Guang Shi, Lan Yang, An-Chen Guo, Jian-Ping Wu, Tie-Shan Tang, Qun Wang   +12 more
doaj   +1 more source

Enterococcus hirae QT4713 alleviated DSS-induced colitis by modulating gut microbiota and tryptophan metabolism in mice

Food Science and Human Wellness
Probiotics are known to alleviate inflammatory bowel disease, and their precise mechanisms remain unclear. In this study, we identified a strain of Enterococcus hirae QT4713, isolated from the Tibetan plateau, that exhibited high anti-inflammatory ...
Xueni Fan, Zhenjiang Liu, Wei Liu, Diantong Li, Tingting Zhao, Dongxu Wen, Xin Li, Qi Wang, Bin Li, Xiaodan Huang   +9 more
doaj   +1 more source

Skin Rejuvenation in Aged Mice by Fecal Transplantation Microbiota from Young Mice Feces

Engineering
Skin aging is an increasingly prominent topic in the context of healthy aging. During the aging process, the skin’s barrier function diminishes, its water content decreases, wrinkles begin to form, and changes occur in the gut microbiota composition ...
Shoujuan Yu, Ziyang Li, Xiaoxu Zhang, Qi Zhang, Liwei Zhang, Liang Zhao, Ping Liu, Jie Guo, Juan Chen, Chengying Zhang, Xinjuan Liu, Mengyang Yu, Dekui Jin, Xiaofeng Wang, Guang Li, Yan Cao, Fazheng Ren, Ran Wang   +17 more
doaj   +1 more source

Lactiplantibacillus plantarum DPUL-S164 regulate aryl hydrocarbon receptors signaling to ameliorate dextran sodium sulfate-induced intestinal barrier damage by producing indole-3-lactic acid in a tryptophan-rich diet

Food Science and Human Wellness
The aim of this paper was to study the effect of combination of Lactobacillus strains and tryptophan (Trp)-rich diet on the intestinal barrier function of Balb/c mice exposed to a cocktail of antibiotics and dextran sodium sulfate.
Arong Wang, Dashuai He, Tieqi Wang, Cheng Guan, Guangqing Mu, Yanfeng Tuo   +5 more
doaj   +1 more source

Dietary tryptophan alleviates intestinal inflammation caused by long photoperiod via gut microbiota derived tryptophan metabolites-NLRP3 pathway in broiler chickens

Poultry Science
: Light pollution is a potential risk factor for intestinal health. Tryptophan plays an important role in the inhibition of intestinal inflammation. However, the mechanism of tryptophan in alleviating intestinal inflammation caused by long photoperiod is
Dandan Ma, Shaoshuai Zhang, Minhong Zhang, Jinghai Feng   +3 more
doaj   +1 more source

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2. [PDF]

J Transl Med, 2023
Zhang FL, Chen XW, Wang YF, Hu Z, Zhang WJ, Zhou BW, Ci PF, Liu KX.   +7 more
europepmc   +1 more source

Diabetes-associated modifications in gut microbiota and tryptophan metabolism: implications for macrophage polarization and wound repair in mice

BMC Microbiology
Background Diabetic wound (DW) is a severe complication of diabetes with poor healing, linked to gut microbiota dysbiosis, metabolic imbalance, and macrophage polarization disorder. This study aimed to systematically explore the role of the gut-skin axis
Yiming Ni, Jiawei Feng, Wei Zhang, Min Tang, Shiyu Wang, Rong Shi, Mingmei Zhou, Cheng Zhao   +7 more
doaj   +1 more source