Results 181 to 190 of about 285,115 (267)

Sulfenylnitrene-mediated aminative cyclizations for the diastereoselective synthesis of fused bicyclic indolines. [PDF]

RSC Adv
Herndon D, Kafle P, Mukherjee R, Sharma I.   +3 more
europepmc   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling. [PDF]

Chin Med
Liang R, Liu X, Chen Q, Zhang M, Xu Y, Shi H, Wang S, Jing W.   +7 more
europepmc   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Indolyl substituted 4-oxobut-2-enoic acids. Synthesis and aza-Michael additions

Open Chemistry, 2007
Berkeš Dušan, Koren̆ová Anna, Šafár̆ Peter, Horváthová Helena, Prónayová Nadežda   +4 more
doaj   +1 more source

Tryptophanase Mining and Characterization toward the Biological Production of Indole Derivatives. [PDF]

ACS Omega
de Boer RM, Harding-Larsen D, Mazurenko S, Welner DH.   +3 more
europepmc   +1 more source

Determination of the structure and dynamics of linear polypeptide gramicidin A at atomic-scale resolution. [PDF]

RSC Adv
Laxmi Pradhan B, Sen P, Kumar A, Bhunia A, Kishor Dey K, Ghosh M.   +5 more
europepmc   +1 more source

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome. [PDF]

J Anim Sci Biotechnol
Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, Ikeda-Ohtsubo W, Agista AZ, Yoshida A, Sakuma T, Fukuda I, Suzuki K, Yoshioka G, Imai Y, Tsuchida S, Nishiyama E, Shinkai H, Muneta Y, Uenishi H, Tobe R, Shirakawa H, Maekawa M, Mano N, Kitazawa H, Nishiyama K.   +23 more
europepmc   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source