Results 211 to 220 of about 285,115 (267)

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids. [PDF]

Nat Commun
Wang L, Liu S, Zi H, Xu R, Qu F, He W, Gan Z, Gao J, Jin Y.   +8 more
europepmc   +1 more source

Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices

Macromolecular Rapid Communications, EarlyView.
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga, Renyu Zheng, Zeqian Zhang, Junhee Lee, Diya Gandhi, Chun‐Long Chen, Andrew L. Ferguson   +6 more
wiley   +1 more source

Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding. [PDF]

Sci Rep
Rady MR, Mabrouk DM, Ibrahim MM.
europepmc   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Halomonas Strain. [PDF]

Mar Drugs
Yan Y, Li Z, Li H, Sun J, Li W, Xiao F.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

A Total Synthesis of (-)-Strychnine Using Photoredox Catalysis. [PDF]

JACS Au
Wiechert R, Geske L, Hammes J, Tuncer D, Opatz T.   +4 more
europepmc   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, EarlyView.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

The Chemistry and Pharmacology of the Alkaloid Barettin and Its Analogues from the Marine Sponge <i>Geodia barretti</i>: Progress and Perspectives. [PDF]

Mar Drugs
Bailly C.
europepmc   +1 more source