Results 41 to 50 of about 285,115 (267)

Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets

, 2015
We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through
Bellina, Bruno, Kresin, Vitaly V., Merthe, Daniel J.   +2 more
core   +1 more source

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]

, 2016
This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed, Baillie, Gemma L., Greig, Iain R., Ross, Ruth A., Trembleau, Laurent   +4 more
core   +1 more source

Synthesis of benzothiophene and indole derivatives through metal-free propargyl–allene rearrangement and allyl migration

Beilstein Journal of Organic Chemistry, 2017
An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao, Yajie Xie, Lianpeng Zhang, Yujin Li, Hongwei Zhou   +4 more
doaj   +1 more source

Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates

ChemistryOpen, 2023
A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives.
Shengnan Sun, Hexia Ye, Haibo Liu, Dr. Yongbiao Guo, Zhenhua Gao, Dr. Li Pan, Dr. Junchen Li, Prof. Dr. Xiaojing Bi   +7 more
doaj   +1 more source

NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2015
Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.
Mukut Gohani, Johannes H. van Tonder, Barend C.B. Benzuidenhoudt   +2 more
doaj  

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I,
Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran   +5 more
doaj   +1 more source

Escaping ESKAPE resistance: in vitro and in silico studies of multifunctional carbamimidoyl-tethered indoles against antibiotic-resistant bacteria

Royal Society Open Science, 2023
Combining the hybridization and repurposing strategies, six compounds from our in-house library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 were repurposed as potential antibacterial agents.
Kanika Gulia, Ahmed H. E. Hassan, Justin R. Lenhard, Abdelbasset A. Farahat   +3 more
doaj   +1 more source

A fluorometric method for the estimation of tryptophan [PDF]

, 1949
The various colorimetric methods now employed for the estimation of tryptophan are not specific for tryptophan but give colored products with many compounds containing the indole nucleus, including indole itself.
Gordon, Malcolm, Mitchell, Herschel K.
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Anti-aphrodisiac compounds of male butterflies increase the risk of egg parasitoid attack by inducing plant synomone production [PDF]

, 2009
During mating in many butterfly species, males transfer spermatophores that contain anti-aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti ...
Fatouros, N.E., Pashalidou, F.G., Aponte Cordero, W.V., Loon, J.J.A., van, Mumm, R., Dicke, M., Hilker, M., Huigens, M.E.   +7 more
core   +2 more sources