Results 41 to 50 of about 329,198 (291)

Novel Inducers of the Envelope Stress Response BaeSR in Salmonella Typhimurium: BaeR Is Critically Required for Tungstate Waste Disposal [PDF]

, 2011
The RpoE and CpxR regulated envelope stress responses are extremely important for SalmonellaTyphimurium to cause infection in a range of hosts. Until now the role for BaeSR in both the Salmonella Typhimurium response to stress and its contribution to ...
AbuOun, Manal, Alston, Mark J., Anjum, Muna F., Appia-Ayme, Corinne, Field, Sarah J., Patrick, Elaine, Rowley, Gary, Sullivan, Matthew J.   +7 more
core   +4 more sources

Synthesis of benzothiophene and indole derivatives through metal-free propargyl–allene rearrangement and allyl migration

Beilstein Journal of Organic Chemistry, 2017
An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao, Yajie Xie, Lianpeng Zhang, Yujin Li, Hongwei Zhou   +4 more
doaj   +1 more source

Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates

ChemistryOpen, 2023
A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives.
Shengnan Sun, Hexia Ye, Haibo Liu, Dr. Yongbiao Guo, Zhenhua Gao, Dr. Li Pan, Dr. Junchen Li, Prof. Dr. Xiaojing Bi   +7 more
doaj   +1 more source

Synthesis of indoles via alkylidenation of acyl hydrazides [PDF]

, 2009
Indoles have been synthesised via alkylidenation of acyl phenylhydrazides using phosphoranes and the Petasis reagent, followed by in situ thermal rearrangement of the product enehydrazines.
Commeureuc, A.G.J., EPSRC (Funder), Hisler, K., Murphy, J.A., WestCHEM (Funder), Zhou, S.Z.   +5 more
core   +1 more source

NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2015
Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.
Mukut Gohani, Johannes H. van Tonder, Barend C.B. Benzuidenhoudt   +2 more
doaj  

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I,
Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran   +5 more
doaj   +1 more source

Escaping ESKAPE resistance: in vitro and in silico studies of multifunctional carbamimidoyl-tethered indoles against antibiotic-resistant bacteria

Royal Society Open Science, 2023
Combining the hybridization and repurposing strategies, six compounds from our in-house library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 were repurposed as potential antibacterial agents.
Kanika Gulia, Ahmed H. E. Hassan, Justin R. Lenhard, Abdelbasset A. Farahat   +3 more
doaj   +1 more source

A fluorometric method for the estimation of tryptophan [PDF]

, 1949
The various colorimetric methods now employed for the estimation of tryptophan are not specific for tryptophan but give colored products with many compounds containing the indole nucleus, including indole itself.
Gordon, Malcolm, Mitchell, Herschel K.
core  

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]

, 2018
Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W., Andersen, Olaf S., Dockendorff, Chris, Dodge, Matthew W., Eum, Kenneth S., Gandhi, Disha M., Ingolfsson, Helgi I., Kapoor, Ruchi, Kimball, Ian H., Martin, Stephen F., Peyear, Thasin, Rusinova, Radda, Sack, Jon T.   +12 more
core   +2 more sources