Results 131 to 140 of about 429,874 (275)

Monoterpenoid Indole Alkaloids from Cultivated in Yunnan

open access: yesNatural Product Communications, 2015
A new monoterpenoid indole alkaloid, 15,20-dehydro-3α-(2-oxopropyl) coronaridine (1) , along with sixteen analogues (2–17) were isolated from the leaves of Catharanthus roseus cultivated in Yunnan.
Bei Wang   +6 more
doaj   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega   +8 more
wiley   +1 more source

Total syntheses of pyrroloazocine indole alkaloids : Challenges and reaction discovery

open access: yes, 2018
Lapidilectines, grandilodines, lundurines and tenuisines are indole alkaloids, isolated from plants of Kopsia genus. They feature a common indole-fused pyrroloazocine core, whose construction poses a significant synthetic challenge.
Miloserdov, Fedor M.   +2 more
core   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

Monoterpene Indole Alkaloids from the Twigs of

open access: yesNatural Product Communications, 2014
The phytochemistry of Kopsia arborea Blume has received considerable attention, which has resulted in the isolation of a number of new unusual indole alkaloids with intriguing structures.
Sarot Cheenpracha   +3 more
doaj   +1 more source

Hepatoprotective Effects of Maillard Reaction Products From Perinereis aibuhitensis: Identification and Metabolomic Insights in a Mouse Model of Alcoholic Liver Disease

open access: yesFood Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract summarizes the hepatoprotective effects of Maillard reaction products derived from Perinereis aibuhitensis (P‐MRPs) in alcohol‐induced liver injury. Male ICR mice were fed a Lieber‐DeCarli alcohol liquid diet (1%–5%, w/v) for 6 weeks with or without P‐MRPs treatment.
Tonglei Qiao   +5 more
wiley   +1 more source

Gut Microbiota‐Dependent Tryptophan Metabolism Drives the Therapeutic Effects of Baitouweng Tang in Colitis via the AhR Pathway

open access: yesFood Science &Nutrition, Volume 14, Issue 10, October 2026.
Baitouweng Tang alleviates colitis symptoms in mice by regulating the structure and diversity of gut microbiota, increasing the content of gut microbiota‐related tryptophan metabolites, activating AhR, inhibiting the release of inflammatory mediators, and improving intestinal homeostasis.
Chun Niu   +6 more
wiley   +1 more source

Early Contributions Leading to Understanding the Significance of Epichloë Endophyte in Temperate Grasses

open access: yesNew Zealand Journal of Agricultural Research, Volume 69, Issue 5, October 2026.
The role and use of Epichloë fungal endophytes in grazed temperate grass pastures and turf grasses are now well understood with regard to balancing pasture persistence while minimising animal health and welfare concerns. However, this understanding has only emerged since the early 1980s. Prior to this, although links between Epichloë endophytes, animal
John R. Caradus   +2 more
wiley   +1 more source

Total synthesis of asperdinones B, C, D, E and terezine D

open access: yesBeilstein Journal of Organic Chemistry
The total synthesis of new members of prenylated indole alkaloids exhibiting α-glucosidase activity is described. Asperdinones B, C, D, and E are characterized by the presence of a (3R)-3-indolylmethylbenzodiazepine-2,5-dione unit at C-3 of C4–C7 ...
Ravi Devarajappa, Stephen Hanessian
doaj   +1 more source

Antimicrobial and Antibiofilm Activity of an Endophytic Fungus, Daldinia sp. Isolated From Avicennia officinalis

open access: yesMicrobiologyOpen, Volume 15, Issue 5, October 2026.
An endophytic fungus (Daldinia sp.) was isolated from the leaves of Avicennia officinalis collected from mangrove forests of Goa. The ethyl acetate extract of Avicennia officinalis (AO‐EA) of the identified endophyte demonstrated antibacterial and antibiofilm activity against Escherichia coli and Shigella sp.
Nickita Dutta   +3 more
wiley   +1 more source

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