Results 91 to 100 of about 149,836 (290)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Genotypic and Phenotypic Heterogeneity in Alicyclobacillus acidoterrestris: A Contribution to Species Characterization. [PDF]

, 2015
Alicyclobacillus acidoterrestris is the main cause of most spoilage problems in fruit juices and acidic products. Since soil borne species often contaminate fruit juices and do not need strict extreme requirements for survival, it is a great concern to
Bevilacqua, A, Ciuffreda, E, Corbo, Mr, Mischitelli, Monica, Pietropaolo, Valeria Antonietta, Sinigaglia, M   +5 more
core   +1 more source

Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses

Gut Pathogens, 2012
Background Many Gram-positive and Gram-negative bacteria produce large quantities of indole as an intercellular signal in microbial communities. Indole demonstrated to affect gene expression in Escherichia coli as an intra-species signaling molecule.
Nikaido Eiji, Giraud Etienne, Baucheron Sylvie, Yamasaki Suguru, Wiedemann Agnès, Okamoto Kousuke, Takagi Tatsuya, Yamaguchi Akihito, Cloeckaert Axel, Nishino Kunihiko   +9 more
doaj   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

High throughput synthesis of 2,5-substituted indoles using a titanium carbenoid bearing boronate functionality [PDF]

, 2008
A titanium benzylidene complex bearing a boronate group converted resin-bound esters into enol ethers. Suzuki cross-coupling with aryl iodides followed by cleavage with acid completed the solid-phase synthesis of 2,5-disubstituted N-Boc-indoles.
Hartley, R.C., Main, C.A., Petersson, H.M., Rahman, S.S.   +3 more
core   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Minitek Inoculum Broth for Testing Indole Production by Enterobacteriaceae

Journal of Food Protection, 1981
With 73 members of the Enterobacteriaceae family, detection of indole production with Minitek inoculum broth (MIB) correlated more closely with the results of the conventional method than did detection with the Minitek H2S/indole disk.
N A, Cox, J E, Thomson, J S, Bailey
openaire   +2 more sources

Fittonia verschaffeltii Response to Artificial Light Treatments: BIOMASS, Nutrient Concentrations and Physiological Changes [PDF]

, 2020
The purpose of the present study was to evaluate the effects of different light treatments on biomass, nutrient concentrations and physiological parameters of Fittonia verschaffeltii (Lem) Van Houtte.
Almansa Espín, Eva María, Barbero Francisco, Francisco J., Chica Moreno, Rosa María, García Caparrós, Pedro, Lao Arenas, María Teresa   +4 more
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Finished Genome Sequence of the Indole-3-Acetic Acid-Catabolizing Bacterium Pseudomonas putida 1290. [PDF]

, 2019
Use of indole-3-acetic acid (IAA) as a carbon, nitrogen, and energy source by Pseudomonas putida 1290 is linked to the possession of a gene cluster that codes for conversion to catechol.
Laird, Tyler S, Leveau, Johan HJ
core