Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. [PDF]
PLoS ONE, 2019 IntroductionDogs with protein-losing enteropathy (PLE) have decreased serum tryptophan concentrations, which may contribute to disease pathogenesis.
Aarti Kathrani +7 more
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Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy [PDF]
BMC Cancer, 2022 Background The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years.
Chie Takasu +10 more
doaj +5 more sources
Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation [PDF]
Memorias do Instituto Oswaldo Cruz, 2014 Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and stimulate effective immune responses by T cells, but can also act as negative regulators of these responses and thus play important roles in immune regulation.
Luciana Cavalheiro Marti +5 more
doaj +5 more sources
Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis [PDF]
Stem Cell Research & Therapy, 2017 Background Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance.
Antonina Coppola +6 more
doaj +3 more sources
The role of the immunoescape in colorectal cancer liver metastasis.
PLoS ONE, 2021 The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This
Chie Takasu +8 more
doaj +2 more sources
Frontiers in Chemistry, 2021 Indoleamine-2,3-dioxygenase (IDO1) and tryptophan dioxygenases are two heme based metalloenzymes that catalyze the tryptophan oxidation reaction by inserting molecular dioxygen to cleave the pyrrole ring.
Jyoti Chauhan +3 more
doaj +1 more source
Frontiers in Immunology, 2022 ObjectiveThe occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention.
Xiaolin Zhang +13 more
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Frontiers in Immunology, 2023 The jaw periosteal tissue is generally recognized as a suitable source for the isolation of mesenchymal stem cells (MSCs). In previous studies we showed evidence that two- and three-dimensionally cultured jaw periosteum-derived MSCs (JPCs) are able to ...
Wanjing Cen +6 more
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Characterization of the blastogenic response to LPS of bovine peripheral blood mononuclear cells. [PDF]
PLoS ONE, 2018 Mitogens are diverse compounds of plant and microbial origin, widely employed to test immunocompetence in animals. The blastogenic response of bovine Peripheral Blood Mononuclear Cells (PBMC) to lypopolysaccharides (LPS) has been investigated in our ...
Massimo Amadori +5 more
doaj +1 more source
SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses. [PDF]
PLoS ONE, 2012 Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation
Cortez McBerry +4 more
doaj +1 more source