Results 91 to 100 of about 18,349 (196)

B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women. [PDF]

, 2014
BACKGROUND: B7 costimulatory molecules are expressed on antigen presenting cells (APCs) and are important regulators of T cell activation. We investigated the role of the B7 family of costimulatory molecules in the development of the systemic maternal ...
A Hutloff, AJ Coyle, Anna Bajnok, B Santner-Nanan, C Herve, CA Chambers, CD Gimmi, DH Munn, Enikő Grozdics, ES Taglauer, G Toldi, G Toldi, G Toldi, Gergely Toldi, Gábor Veres, István Ilisz, János Rigó, KJ Swartz, L Vecsei, L Vécsei, LP Jin, László Berta, László Vécsei, MG Petroff, Péter Klivényi, S Saito, S Wang, Tivadar Tulassay, U Grohmann, U Grohmann, Y Mándi   +30 more
core   +2 more sources

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Mesenchymal stem cells for management of rheumatoid arthritis : immune modulation, repair or both? [PDF]

, 2018
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050, 20775) and the Medical Research Council (grant no.
Ansboro, Sharon, de Bari, Cosimo, Roelofs, Anke J.   +2 more
core   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells

Viruses, 2020
Reactivation of BK polyomavirus (BKPyV) infection is frequently increasing in transplant recipients treated with potent immunosuppressants and highlights the importance of immune system components in controlling viral reactivation.
Tony Fiore, Elodie Martin, Véronique Descamps, Etienne Brochot, Virginie Morel, Lynda Handala, Fatima Dakroub, Sandrine Castelain, Gilles Duverlie, François Helle, Catherine François   +10 more
doaj   +1 more source

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma [PDF]

, 2020
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy.
Bhushan, Alok, Kaushal, Gagan, Lam, Bao, Link, Emma, Londin, Eric R, Orloff, Marlana, Rochani, Ankit, Sato, Takami, Terai, Mizue   +8 more
core   +1 more source

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation [PDF]

, 2016
Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines.
Amberger, Barnes, Bradfield, Bruder, Carding, Carlin, Carlin, Costa, Daubener, Daubener, Daubener, Dittrich, Else, Ernst, Ghaemmaghami, Ghaemmaghami, Ghaemmaghami, Gordon, Gosset, Grohmann, Hammad, Hammad, Hayaishi, Hayday, Holt, Hooks, Hunstad, Khademhosseini, Kishimoto, Lambrecht, Langridge, Liu, Mellor, Mellor, Mellor, Mellor, Mellor, Mellor, Mellor, Michelson, Nagase, Namboodiri, Ochs, Opelz, Pallet, Peng, Platten, Platten, Pogue, Puccetti, Puccetti, Puccetti, Puccetti, Raz, Schneider-Schaulies, Schultze, Schwarze, Taylor, Terness, Thomas, Van den Eynde, Van den Eynde, van Oosterhout, Witkiewicz, Wurtzen, Zurawski   +65 more
core   +1 more source

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism

Pharmaceuticals, 2010
Phytocannabinoids present in Cannabis plants are well known to exert potent anti-inflammatory and immunomodulatory effects. Previously, we have demonstrated that the psychoactive D9-tetrahydrocannabinol (THC) and the non-psychotropic cannabidiol (CBD ...
Dietmar Fuchs, Sebastian Schröcksnadel, Florian Überall, Marcel Jenny   +3 more
doaj   +1 more source

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

, 2013
Background: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia.
Bode-Böger, S.M. (Stefanie), Kielstein, J.T. (Jan), Kovesdy, C.P. (Csaba), Kümpers, P. (Philipp), Martens-Lobenhoffer, J. (Jens), Meurs, M. (Matijs) van, Padberg, J. (Jan), Zijlstra, J.G. (Jan)   +7 more
core   +1 more source