Results 121 to 130 of about 18,349 (196)

Effect of Indoleamine 2,3 Dioxygenase Inhibitor on the Cytotoxic Activity of Tumour-infiltrating Lymphocytes

Acta Dermato-Venereologica, 2019
is missing (Short communication)
Sarah Le Naour, Anne-Chantal Knol, Marie-Christine Pandolfino, Amir Khammari, Brigitte Dréno   +4 more
doaj   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Wine and Grape Juice Modulate Interferon-y-induced Neopterin Production and Tryptophan Degradation in Human PBMC

Pteridines, 2004
Population-based studies suggest moderate and regular consumption of alcoholic beverages and especially of red wine to reduce morbidity and mortality from coronary heart disease.
Neurauter Gabriele, Wirleitner Barbara, Schroecksnadel Katharina, Schennach Harald, Fuchs Dietmar   +4 more
doaj   +1 more source

The Double‐Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health

Obesity Reviews, EarlyView.
ABSTRACT Although much research focuses on the effects of hyperglycemia during pregnancy on maternal and offspring health, this narrative review specifically centers on the role of insulin resistance (IR) in pregnancy complications and offspring long‐term health.
Runyu Du, Fei Wang, Ling Li, Qiuyue Wang
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Exercise‐induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV‐associated atherosclerosis mouse model

Experimental Physiology, EarlyView.
Abstract A mouse model of HIV‐associated atherosclerosis (Tg26+/−ApoE−/−) exhibited increased plaque area compared with the ApoE−/− mouse, linked to elevated indoleamine 2,3‐dioxygenase (IDO) activity. IDO catalyses the conversion of tryptophan (TRP) into kynurenine (KYN), measured by the KYN‐to‐TRP ratio.
Marcus V. S. Rangel, Mohammad Afaque Alam, Mohammad Islamuddin, Zheng Chen, Xuebin Qin, Juliana P. Borges   +5 more
wiley   +1 more source

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma

Pteridines, 2017
As the disease-free 5-year-survival of late stage laryngeal carcinoma patients is extremely low, indoleamine-2,3-dioxygenase-1 (IDO)-induced tryptophan degradation may represent an immune escape mechanism which plays an important role in cancer spreading
Engin Ayse Basak, Gunaydin Riza Onder, Kesikli Sacit Altug, Fuchs Dietmar, Hosal Ali Sefik   +4 more
doaj   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Cancer Comorbidities: Clinical Impacts, Mechanistic Insights, and Management Strategies

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review focuses on cancer comorbidities, examining their clinical impacts and mechanistic insights. It further examines key management challenges, including evidence gaps, the lack of precise assessment tools, limited management frameworks, and underdeveloped multidisciplinary collaborations.
Taoxing Peng, Siyi Chen, Xin He, Yuxin Yang, Yuexiang Ren, Yuxuan Sun, Fuli Shi, Yangfeng Lv, Xiangqiong Wen, Yujian Wen, Peng Yu, Weizhu Liu, Qiongfeng Chen, Xianhe Yang, Shan Xu, Jianming Li   +15 more
wiley   +1 more source

Indoleamine 2,3-Dioxygenase (IDO) [PDF]

The American Journal of Pathology, 2007
Marina Scheler, Joerg Wenzel, Thomas Tüting, Osamu Takikawa, Thomas Bieber, Dagmar von Bubnoff   +5 more
openaire   +1 more source