Results 131 to 140 of about 18,349 (196)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Cell and Gene Therapy in Equine Ocular Disease

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young, Lauren V. Schnabel, Brian C. Gilger   +2 more
wiley   +1 more source

Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta‐Analysis

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
This systematic review and meta‐analysis, which examined the effects of acute endurance training on immunoregulatory myokines, showed significant small‐moderate to very large positive effect sizes for IL‐6, IL‐10, IL‐1ra, IL‐8, IL‐15, and TNF‐α. These effects were significantly moderated by risk of bias, sex, age, V̇O2peak, experience, type of exercise,
Miriam Ringleb, Fabian Fabritius, Jakob Godde, Christian Puta, Wilhelm Bloch, Florian Javelle   +5 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, Volume 16, Issue 2, Page 432-446, February 2026.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection [PDF]

, 2007
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance.
Aldabe, R. (Rafael), Casares, N. (Noelia), Civeira, M.P. (María Pilar), Gil-Guerrero, L. (Lucía), Heeney, J.L. (Jonathan L.), Larrea, E. (Esther), Riezu-Boj, J.I. (José Ignacio), Rollier, C.S. (Christine S.), Sarobe, P. (Pablo), Verstrepen, B.E. (Babs E.)   +9 more
core  

Association Between Peripheral IL‐6 Levels in the Acute Stage of Stroke and Poststroke Depression: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
This is a meta‐analysis on the relationship between IL‐6 concentration in the acute phase of stroke and poststroke depression. Higher peripheral IL‐6 concentrations in the acute stage of stroke are closely related to the risk of PSD; collecting samples within 1 day after stroke onset and evaluating depression post discharge are recommended.
Hongmin Gong, Jiaqin Yuan, Min Li, Deqi Xiong, Fayang Ling, Mei Liu, Yan Hu, Shouqiang Wang   +7 more
wiley   +1 more source

Reactivities of indoleamine 2,3-dioxygenases

, 2013
The heme enzyme indoleamine 2,3-dioxygenase (IDO1) catalyzes L-Trp oxidation in non-hepatic mammalian tissues by inserting both atoms of dioxygen into the indole ring to form N-formylkynurenine. In the present work, IDO1 was found to oxidize β-NADH under aerobic conditions in the absence of other reactants.
openaire   +1 more source

A Case Report of a Multisystemic Immune‐Related Adverse Event Caused by Sintilimab in Combination With Thymosin Alpha‐1

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune‐related adverse events (irAEs) after treatment with sintilimab (PD‐1 inhibitor) in combination with thymosin alpha‐1 (Tα1). The patient presents with high fever, rash, interstitial pulmonary edema, and multiple organ failure.
Ting Li, Bao‐Liang Wu, Cai‐Long Yu, Liang‐Yan Jin   +3 more
wiley   +1 more source

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

Scientific Reports
Tryptophan-2,3-dioxygenase (TDO2) and indoleamine-2,3-dioxygenase (IDO1) are structurally distinct heme enzymes that catalyze the conversion of L-tryptophan to N-formyl-kynurenine, and play important roles in metabolism, inflammation, and tumor immune ...
Carina Lotz-Jenne, Roland Lange, Sylvaine Cren, Geoffroy Bourquin, Laksmei Goglia, Thierry Kimmerlin, Micha Wicki, Manon Müller, Nadia Artico, Sabine Ackerknecht, Philippe Pfaff, Christoph Joesch, Aengus Mac Sweeney   +12 more
doaj   +1 more source