Results 151 to 160 of about 18,349 (196)
Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders
Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng +19 more
wiley +2 more sources
Thoracic Cancer, Volume 17, Issue 3, February 2026.This systematic review and meta‐analysis (100 trials, 9192 patients) clarifies breast cancer ICI‐based combination toxicity hierarchies. ICI‐ADC has higher grade ≥ 3 TRAEs; ICI‐mTKI has the worst irAEs, while ICI‐PARPi/HER2‐targeted combinations present the lowest risks.
Yunwei Lu +4 more
wiley +1 more source
Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma
Cancer Science, Volume 117, Issue 2, Page 325-334, February 2026.IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina +18 more
wiley +1 more source
Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]
, 2015 Guerrant, RL +10 more
core +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang +18 more
wiley +1 more source
International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari +2 more
wiley +1 more source
T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri +7 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.This review surveys recent progress in the synthesis of extended aromatic quinolizinium derivatives via intramolecular SNAr and oxidative 6π‐electrocyclization. Conventional thermal approaches are discussed alongside emerging, sustainable activation methods such as electrosynthesis and photochemical processes.
Marine Labro +2 more
wiley +1 more source