Results 21 to 30 of about 18,349 (196)

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Frontiers in Immunology, 2015
The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes ...
Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs   +4 more
doaj   +1 more source

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

Frontiers in Cellular Neuroscience, 2021
Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN).
Ning Deng, Jiao Hu, Yu Hong, Yu Hong, Yuewen Ding, Yuewen Ding, Yifan Xiong, Zhiyong Wu, Zhiyong Wu, Wei Xie, Wei Xie   +10 more
doaj   +1 more source

Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]

, 2017
In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core   +1 more source

IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression

OncoImmunology, 2017
Mycosis fungoides (MF) progresses from patch to tumor stage by expansion of malignant T-cells that fail to be controlled by protective immune mechanisms. In this study, we focused on IL-32, a cytokine, highly expressed in MF lesions.
Hanako Ohmatsu, Daniel Humme, Juana Gonzalez, Nicholas Gulati, Markus Möbs, Wolfram Sterry, James G. Krueger   +6 more
doaj   +1 more source

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

The role of placental tryptophan catabolism

Frontiers in Immunology, 2014
This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focussing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of ...
Peter eSedlmayr, Astrid eBlaschitz, Roland eStocker   +2 more
doaj   +1 more source

Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation [PDF]

, 2012
[Abstract] Background. The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations.
Barge-Caballero, Eduardo, Castro-Beiras, Alfonso, Crespo-Leiro, María Generosa, Domenech-García, Nieves, Grille Cancela, Zulaika, Marzoa Rivas, Raquel, Muñiz, Javier, Paniagua-Martín, María J., Pombo-Otero, Jorge, Suárez-Fuentetaja, Natalia   +9 more
core   +3 more sources

Contribution of indoleamine 2,3-dioxygenase in preeclampsia

Al-Azhar Assiut Medical Journal, 2016
Background Preeclampsia (PE) is a complex, multiorgan disease that leads to maternofetal morbidity and mortality. Increasing evidence now indicates that PE may have an immunological cause.
Mona F.M El-Karn, Hayam G Sayyed, Safwat A Mohammed, Nemah M.A Abdulrab   +3 more
doaj   +1 more source

Pre-conditioning of Equine Bone Marrow-Derived Mesenchymal Stromal Cells Increases Their Immunomodulatory Capacity

Frontiers in Veterinary Science, 2020
Mesenchymal stem/stromal cells (MSCs) are increasingly explored for the treatment of degenerative and inflammatory diseases in human and veterinary medicine.
Valeria Caffi, Valeria Caffi, Gabriel Espinosa, Gonzalo Gajardo, Natalia Morales, María Carolina Durán, Benjamín Uberti, Gabriel Morán, Anita Plaza, Claudio Henríquez   +9 more
doaj   +1 more source

Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS. [PDF]

, 2019
PurposeTo evaluate relationships among retinal vascular caliber and biomarkers of systemic inflammation in patients with AIDS.MethodsA total of 454 participants with AIDS had retinal vascular caliber (central retinal artery equivalent and central retinal
Cheu, Ryan, Danis, Ronald P, Hunt, Peter W, Jabs, Douglas A, Jones, Norman, Klatt, Nichole R, Milush, Jeffrey M, Pak, Jeong Won, Trang, Garrett, Van Natta, Mark L   +9 more
core   +1 more source