Results 81 to 90 of about 18,349 (196)

INDOLEAMINE 2,3 DIOXYGENASE AS AN IMMUNOTHERAPEUTIC TARGET BRINGS A NEW HOPE FOR CANCER PATIENTS

Journal of Cancer and Allied Specialties, 2018
Therapeutic manipulation of immune system in cancer has been an extensive area of research in the field of oncoimmunology. Immunotherapy helps the immune system to combat against cancer.
Kashif Asghar, Asif Loya
doaj   +1 more source

A CD8 T Cell/Indoleamine 2,3-Dioxygenase Axis Is Required for Mesenchymal Stem Cell Suppression of Human Systemic Lupus Erythematosus [PDF]

, 2014
published_or_final_versio
Chen, Wanjun, Chen, Zhiyong, Feng, Xuebing, Gao, Xiang, Konkel, Joanne E, Li, Xia, Lu, Lin, Lu, Liwei, Shi, Songtao, Sun, Lingyun, Wang, Dandan, Zhang, Huayong   +11 more
core   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Structure–activity relationship studies of 5-(Pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 inhibitors

Results in Chemistry
Indoleamine 2,3-dioxygenase 1 (IDO1) is the key enzyme that catalyzes the conversion of l-tryptophan (Trp) to N-formyl-kynurenine in the tryptophan-kynurenine (Trp-Kyn) pathway.
Jiawei Zhang, Jingyi Liu, Kaimin Kong, Xingzhou Li, Qian Zhang   +4 more
doaj   +1 more source

Involvement of the kynurenine pathway in human glioma pathophysiology.

PLoS ONE, 2014
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the ...
Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +9 more
doaj   +1 more source

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

Frontiers in Immunology, 2020
Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated.
Martina Mandarano, Guido Bellezza, Maria Laura Belladonna, Jacopo Vannucci, Alessio Gili, Ivana Ferri, Chiara Lupi, Vienna Ludovini, Giulia Falabella, Giulio Metro, Giada Mondanelli, Rita Chiari, Lucio Cagini, Fabrizio Stracci, Fabrizio Stracci, Fausto Roila, Francesco Puma, Claudia Volpi, Angelo Sidoni   +18 more
doaj   +1 more source

Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents : a cross-sectional analysis of two cohorts [PDF]

, 2018
Background: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown.
Carvalho, Livia A, Clarke, Gerard, Díaz, Ligia Esperanza, Gómez-Martínez, Sonia, Marcos, Ascensión, Michels, Nathalie, Olavarria-Ramirez, Loreto, Widhalm, Kurt   +7 more
core   +2 more sources

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice

Neuropsychopharmacology Reports, 2018
Aim Indoleamine 2,3‐dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP).
Nao Hirata, Satoko Hattori, Hirotaka Shoji, Hiroshi Funakoshi, Tsuyoshi Miyakawa   +4 more
doaj   +1 more source

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]

, 2019
PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania, Lee, Mi-Heon, McBride, William H, Nesseler, Jean Philippe, Nickers, Philippe, Niclou, Simone P, Schaue, Dorthe   +6 more
core