Results 211 to 220 of about 29,794,370 (246)

Tryptophan deficiency induced by indoleamine 2,3-dioxygenase 1 results in glucose transporter 1-dependent promotion of aerobic glycolysis in pancreatic cancer. [PDF]

MedComm (2020)
Liang H, Zhan J, Chen Y, Xing Z, He ZNT, Liu Y, Li X, Chen Y, Li Z, Kuang C, Yang D, Yang Q.   +11 more
europepmc   +1 more source

Improved automated one-pot two-step radiosynthesis of (S)-[¹⁸F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1). [PDF]

EJNMMI Radiopharm Chem
Maisonial-Besset A, Kryza D, Kopka K, Levesque S, Moreau E, Wenzel B, Chezal JM.   +6 more
europepmc   +1 more source

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Indoleamine 2,3-Dioxygenase-1 Expression in Adrenocortical Carcinoma

Journal of Surgical Research, 2020
Indoleamine 2,3-dioxygenase 1 (IDO-1) is overexpressed in many human carcinomas and a successful target for therapy in mouse models. Prognosis of patients with advanced adrenocortical carcinoma (ACC) is poor due to the lack of effective treatments, and new therapies are therefore needed.
John F, Tierney, Alyx, Vogle, Brendan, Finnerty, Rasa, Zarnegar, Ritu, Ghai, Paolo, Gattuso, Thomas J, Fahey, Xavier M, Keutgen   +7 more
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Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta

Journal of Reproductive Immunology, 2004
Studies in mice have suggested that the placenta is protected from immune rejection by maternal T cells by means of localised indoleamine 2,3-dioxygenase dependent depletion of tryptophan.
Yoshiki Kudo, Osamu Takikawa, I L Sargent   +2 more
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Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1)

Journal of Medicinal Chemistry, 2019
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging. Its implication in pathologies such as cancer and neurodegenerative diseases has stimulated the development of IDO1 inhibitors.
Ute F. Röhrig, Aline Reynaud, Somi Reddy Majjigapu, Pierre Vogel, Florence Pojer, Vincent Zoete   +5 more
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Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice

Toxicology and Applied Pharmacology, 2020
Indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase 2 (TDO2) degrade tryptophan (Trp) to kynurenine (Kyn), and these enzymes have promise as therapeutic targets. A comprehensive characterization of potential safety liabilities of IDO1 and TDO2 inhibitors using knockout (KO) mice has not been assessed, nor has the dual Ido1/Tdo2 KO been ...
Amy G, Aslamkhan, Qiuwei, Xu, Amy, Loughlin, Heather, Vu, Stephen, Pacchione, Bhavana, Bhatt, Ivy, Garfinkel, Tara Grady, Styring, Lisa, LaFranco-Scheuch, Kara, Pearson, Spencer, Reynolds, Nianyu, Li, Heather, Zhou, J Richard, Miller, Nicolas, Solban, Alan, Bass, Warren E, Glaab   +16 more
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Indoleamine 2,3-dioxygenase 1 in circumventing checkpoint inhibitor responses: Updated

International Immunopharmacology, 2023
Metabolic alterations occur commonly in tumor cells as a way to adapt available energetic sources for their proliferation, survival and resistance. Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular enzyme catalyzing tryptophan degradation into kynurenine.
Arian Charehjoo, Jamal Majidpoor, Keywan Mortezaee   +2 more
openaire   +2 more sources

Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase

Bioorganic & Medicinal Chemistry Letters, 2020
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are promising drug development targets due to their implications in pathologies such as cancer and neurodegenerative diseases. The search for IDO1 inhibitor has been intensely pursued but there is a paucity of potent TDO and IDO1/TDO dual inhibitors.
Yuanyuan Li, Shengnan Zhang, Rong Wang, Menghan Cui, Wei Liu, Qing Yang, Chunxiang Kuang   +6 more
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Investigation of indoleamine 2,3-dioxygenase 1 expression in uveal melanoma

Experimental Eye Research, 2019
The purpose of this study was to investigate indoleamine 2,3-dioxygenase 1 (IDO1) expression and its implications in uveal melanoma (UM). Bioinformatics analysis was performed on microarray data (GSE22138 and GSE27831) from the Gene Expression Omnibus (GEO) database to evaluate IDO1 expression in mRNA level.
Chen, Liang, Lanya, Peng, Shaoxue, Zeng, Qing, Zhao, Linqiao, Tang, Xiaoshuang, Jiang, JunJun, Zhang, Naihong, Yan, YingYing, Chen   +8 more
openaire   +2 more sources

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

Amino Acids, 2014
Indoleamine 2,3-dioxygenase-2 (IDO2) is one of three enzymes (alongside tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase (IDO1)) that catalyse dioxygenation of L-tryptophan as the first step in the kynurenine pathway. Despite the reported expression of IDO2 in tumours, some fundamental characteristics of the enzyme, such as substrate ...
Georgios, Pantouris, Martynas, Serys, Hajime J, Yuasa, Helen J, Ball, Christopher G, Mowat   +4 more
openaire   +2 more sources