Results 121 to 130 of about 104,731 (310)

Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos

Angewandte Chemie, EarlyView.
We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif, Luke A. McCall, Matthew G. Sanders, Robert J. Phipps   +3 more
wiley   +2 more sources

Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles

Beilstein Journal of Organic Chemistry, 2014
The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described.
Antonio Arcadi, Emanuela Pietropaolo, Antonello Alvino, Véronique Michelet   +3 more
doaj   +1 more source

Engineering Active Metal and Nonmetal Sites in Porous Structures of Metal‐Hydroxide Clusters for Enhanced D2/H2 Uptake and Separation

Advanced Science, EarlyView.
Two supramolecular assembly frameworks, constructed from metal‐hydroxide clusters, are synthesized via coordination‐driven self‐assembly mediated by Co2+ and Cu2+ metal centers. One of them demonstrates exceptional D2 and H2 uptake capabilities, achieving the second‐highest uptake capacity for D2.
Zhuozhou Xie, Zhu Zhuo, Zi‐Ang Nan, Qing Li, Wenlin Wu, Yunzhe Zhou, Zi‐Xiu Lu, Jin Liu, Luyao Liu, Wenjing Wang, Daqiang Yuan, You‐Gui Huang   +11 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins

Beilstein Journal of Organic Chemistry, 2014
A range of phosphinoylindoles was prepared in one-pot from functionalized propargyl alcohols and a suitable P(III) precursor via a base-mediated reaction. The reaction proceeds via the intermediacy of allenylphosphine oxides.
G. Gangadhararao, Ramesh Kotikalapudi, M. Nagarjuna Reddy, K. C. Kumara Swamy   +3 more
doaj   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Stereodivergent Synthesis of Three Contiguous Stereogenic Centers by Cu/Ir‐Catalyzed Borylallylation

Angewandte Chemie, EarlyView.
An alkene borylallylation strategy enabled by cooperative Cu/Ir‐catalysis has been uncovered for accessing three contiguous stereogenic centres. This strategy is notable given the inherent challenges of constructing molecules with multiple stereocenters while maintaining high selectivity bearing diverse functional groups.
Suman Das, Stanna K. Dorn, M. Kevin Brown   +2 more
wiley   +2 more sources

Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models

Anais da Academia Brasileira de Ciências
The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed
BENEDITO P. SOUSA-NETO, BRUNO S. GOMES, FRANCISCO V.M. CUNHA, DANIEL D.R. ARCANJO, STANLEY J.C. GUTIERREZ, MARIA F.V. SOUZA, FERNANDA R.C. ALMEIDA, FRANCISCO A. OLIVEIRA   +7 more
doaj   +1 more source

Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration

Beilstein Journal of Organic Chemistry, 2014
The reaction of 3-substituted indoles with dehydroalanine (Dha) derivatives under Lewis acid-mediated conditions has been investigated. The formation of 2-substituted tryptophans is proposed to occur through a selective alkylative dearomatization ...
Michele Mari, Simone Lucarini, Francesca Bartoccini, Giovanni Piersanti, Gilberto Spadoni   +4 more
doaj   +1 more source