Results 131 to 140 of about 172,313 (331)

Interrupted Barton–Zard Reaction/Friedel–Crafts Alkylation Telescoped Reaction for the Synthesis of Pyrrolo[3,4‐b]indole Cores

Asian Journal of Organic Chemistry, EarlyView.
An interrupted Barton–Zard reaction/Friedel–Crafts alkylation telescoped reaction provides aryl‐substituted pyrrolo[3,4‐b] cores in moderate‐to‐good yields as mostly single diastereomers. The reaction is tolerant of a wide range of electron‐deficient indoles and (hetero)aromatic nucleophiles, offering a modular approach for the synthesis of multi ...
Josip Rešetar, Karla Remar, Ana Mikleušević, Josipa Suć Sajko, Ines Bašić, Matija Gredičak   +5 more
wiley   +1 more source

Access to N‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives

Angewandte Chemie, EarlyView.
The first general synthetic access to N‐CH₂F and N‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds is disclosed. The method involves the direct synthesis of carbamoyl fluoride building blocks from readily available amines, followed by their derivatization. Abstract This work presents the first general synthetic access to
Filip G. Zivkovic, Fritz Bahns, Che‐Ming Hsu, Franziska Schoenebeck   +3 more
wiley   +2 more sources

Competitive Action of Isonicotinic Acid Hydrazide and Vitamin B6 in the Formation of Indole by E. coli [PDF]

, 1952
Masahiko Yoneda, Nobuo Kato, Mitsuharu Okajima   +2 more
openalex   +1 more source

Exploiting 3‐Methyleneisoindolinones as In Situ Generated Reactive Intermediates in the Synthesis of Tetrasubstituted Carbon Center

Asian Journal of Organic Chemistry, EarlyView.
A straightforward method for constructing a tetrasubstituted carbon center through the in situ formation of 3‐methyleneisoindolinones as reactive intermediates has been developed. This process involves an acid‐catalyzed Meyer‐Schuster rearrangement of isoindolinone‐based propargylic alcohols, followed by an intermolecular Friedel‐Crafts alkylation ...
Arben Beriša, Filip Duplić, Marko Purić, Matija Gredičak, Nikola Topolovčan   +4 more
wiley   +1 more source

Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands

Angewandte Chemie, EarlyView.
This study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Christopher R. Fullenkamp, Shams Mehdi, Christopher P. Jones, Logan Tenney, Patricio Pichling, Peri R. Prestwood, Adrian R. Ferré‐D'Amaré, Pratyush Tiwary, John S. Schneekloth   +8 more
wiley   +2 more sources

Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function

Microorganisms
Gut microbes supporting body growth are known but the mechanisms are less well documented. Using the microbial tryptophan metabolite indole, known to regulate prokaryotic cell division and metabolic stress conditions, we mono-colonized germ-free (GF ...
Peter Yuli Xing, Ruchi Agrawal, Anusha Jayaraman, Katherine Ann Martin, George Wei Zhang, Ee Ling Ngu, Llanto Elma Faylon, Staffan Kjelleberg, Scott A. Rice, Yulan Wang, Adesola T. Bello, Elaine Holmes, Jeremy K. Nicholson, Luke Whiley, Sven Pettersson   +14 more
doaj   +1 more source

Indole Tolerance and the Influence of Aureomycin in the Growing Chick

, 1957
Ellen Wisman, R.W. Engel, C.E. Holmes
openalex   +1 more source

The coli-tryptophan-indole reaction [PDF]

, 1935
Frank Charles Happold, L. Hoyle
openalex   +1 more source

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

Animal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen, Rui‐Rui Gao, Yan‐Yan Chen, Yi‐Jie Wang, Xin‐Tong Wang, Hai‐Xin Liu   +5 more
wiley   +1 more source

Harnessing Negative Photochromism in Styryl Cyanines for Light‐Modulated Proton Transport

Angewandte Chemie, EarlyView.
We show how photo switchable styryl cyanines undergo an extremely efficient photochemical ring‐closing reaction upon irradiation. Furthermore, substituents on the ring and the nature of their surroundings can be used to tune their chemistry, kinetics, and photochemical properties. Finally, we demonstrate how these molecules can be used as smart dopants
Gianni Pacella, Maria Nabatova, Yuxuan Zhang, David Picconi, Roza R. Weber, Shirin Faraji, Giuseppe Portale   +6 more
wiley   +2 more sources